Cargando…

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

BACKGROUND: Activated microglia are a feature of the host response to neurodegeneration in Parkinson's disease (PD) and are thought to contribute to disease progression. Recent evidence suggests that extracellular α-synuclein (eSNCA) may play an important role in the pathogenesis of PD and that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Couch, Yvonne, Alvarez-Erviti, Lydia, Sibson, Nicola R, Wood, Matthew JA, Anthony, Daniel C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239418/ https://www.ncbi.nlm.nih.gov/pubmed/22122884 http://dx.doi.org/10.1186/1742-2094-8-166

Ejemplares similares

Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers
por: Boi, Laura, et al.
Publicado: (2020)

Intranigral Injection of Endotoxin Suppresses Proliferation of Hippocampal Progenitor Cells
por: Darwish, Batoul, et al.
Publicado: (2019)

Alkaloids from piper longum protect dopaminergic neurons against inflammation-mediated damage induced by intranigral injection of lipopolysaccharide
por: He, Huan, et al.
Publicado: (2016)

Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection
por: Li, Da-Wei, et al.
Publicado: (2019)

Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat
por: Soto-Rojas, Luis O., et al.
Publicado: (2020)

Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation: Relevance for Parkinson’s Disease
por: Droguerre, Marine, et al.
Publicado: (2022)

Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson’s Disease
por: Murgia, Federica, et al.
Publicado: (2020)

The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex
por: Palmas, Maria Francesca, et al.
Publicado: (2022)

Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease
por: Dakik, Hassan, et al.
Publicado: (2021)

Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease
por: Wang, Xin-Hong, et al.
Publicado: (2017)

Long-Term Evaluation of Intranigral Transplantation of Human iPSC-Derived Dopamine Neurons in a Parkinson’s Disease Mouse Model
por: Brot, Sébastien, et al.
Publicado: (2022)

Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra
por: Luna-Herrera, Claudia, et al.
Publicado: (2020)

Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons
por: Machado, A., et al.
Publicado: (2011)

Blockade of Intranigral and Systemic D3 Receptors Stimulates Motor Activity in the Rat Promoting a Reciprocal Interaction among Glutamate, Dopamine, and GABA
por: Rodríguez-Sánchez, Marina, et al.
Publicado: (2019)

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
por: Alvarez-Erviti, Lydia, et al.
Publicado: (2011)

Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord
por: Izco, Maria, et al.
Publicado: (2023)

Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease
por: Alvarez-Erviti, L, et al.
Publicado: (2013)

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice
por: Rutherford, Nicola J., et al.
Publicado: (2015)

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
por: Cooper, J Mark, et al.
Publicado: (2014)

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport
por: Wijesekara, Nadeeja, et al.
Publicado: (2021)

Systemic inflammation alters central 5-HT function as determined by pharmacological MRI
por: Couch, Yvonne, et al.
Publicado: (2013)

Spred-2 Deficiency Exacerbates Lipopolysaccharide-Induced Acute Lung Inflammation in Mice
por: Xu, Yang, et al.
Publicado: (2014)

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds
por: Macdonald, Jennifer A., et al.
Publicado: (2021)

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration
por: Peralta Ramos, Javier María, et al.
Publicado: (2019)

ASC specks exacerbate α‑synuclein pathology via amplifying NLRP3 inflammasome activities
por: Zheng, Ran, et al.
Publicado: (2023)

Corrigendum to “Systemic inflammation alters central 5-HT function as determined by pharmacological MRI” [Neuroimage 75 (2013) 177–186]
por: Couch, Yvonne, et al.
Publicado: (2014)

Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson’s disease through TLR2/NF-κB pathway
por: Sun, Li, et al.
Publicado: (2021)

α-Synuclein liquid condensates fuel fibrillar α-synuclein growth
por: Piroska, Leonard, et al.
Publicado: (2023)

Central and peripheral α‐synuclein in Parkinson disease detected by seed amplification assay
por: Chahine, Lana M., et al.
Publicado: (2023)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

α-Tocopherol Restriction Exacerbated Lipopolysaccharide-Induced Inflammatory Response in α-Tocopherol Transfer Protein-Null Mice
por: Hashida, Megumi, et al.
Publicado: (2022)

Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells
por: Shin, Woo Hyun, et al.
Publicado: (2020)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse
por: Delayre-Orthez, Carine, et al.
Publicado: (2005)

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology
por: Jin, Yunjung, et al.
Publicado: (2022)

Altered Gut Microbiome in Parkinson’s Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model
por: Gorecki, Anastazja M., et al.
Publicado: (2019)

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration
por: Harms, Ashley S., et al.
Publicado: (2017)

Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
por: Recasens, Ariadna, et al.
Publicado: (2018)

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients
por: Piancone, Federica, et al.
Publicado: (2021)

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?
por: Lema Tomé, Carla M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_k2o9bkrv8jslqod5msds2jlkl0