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Microbial production of hyaluronic acid: current state, challenges, and perspectives

Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA fin...

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Detalles Bibliográficos
Autores principales: Liu, Long, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Chen, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239841/
https://www.ncbi.nlm.nih.gov/pubmed/22088095
http://dx.doi.org/10.1186/1475-2859-10-99
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author Liu, Long
Liu, Yanfeng
Li, Jianghua
Du, Guocheng
Chen, Jian
author_facet Liu, Long
Liu, Yanfeng
Li, Jianghua
Du, Guocheng
Chen, Jian
author_sort Liu, Long
collection PubMed
description Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals. Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges.
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spelling pubmed-32398412011-12-16 Microbial production of hyaluronic acid: current state, challenges, and perspectives Liu, Long Liu, Yanfeng Li, Jianghua Du, Guocheng Chen, Jian Microb Cell Fact Review Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals. Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges. BioMed Central 2011-11-16 /pmc/articles/PMC3239841/ /pubmed/22088095 http://dx.doi.org/10.1186/1475-2859-10-99 Text en Copyright ©2011 Liu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Liu, Long
Liu, Yanfeng
Li, Jianghua
Du, Guocheng
Chen, Jian
Microbial production of hyaluronic acid: current state, challenges, and perspectives
title Microbial production of hyaluronic acid: current state, challenges, and perspectives
title_full Microbial production of hyaluronic acid: current state, challenges, and perspectives
title_fullStr Microbial production of hyaluronic acid: current state, challenges, and perspectives
title_full_unstemmed Microbial production of hyaluronic acid: current state, challenges, and perspectives
title_short Microbial production of hyaluronic acid: current state, challenges, and perspectives
title_sort microbial production of hyaluronic acid: current state, challenges, and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239841/
https://www.ncbi.nlm.nih.gov/pubmed/22088095
http://dx.doi.org/10.1186/1475-2859-10-99
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