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Endothelial activation: intracellular signaling pathways
CHAPTER SUMMARY: Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240152/ https://www.ncbi.nlm.nih.gov/pubmed/12110129 http://dx.doi.org/10.1186/ar576 |
| _version_ | 1782219349611773952 |
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| author | Pober, Jordan S |
| author_facet | Pober, Jordan S |
| author_sort | Pober, Jordan S |
| collection | PubMed |
| description | CHAPTER SUMMARY: Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules. |
| format | Online Article Text |
| id | pubmed-3240152 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2002 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-32401522011-12-16 Endothelial activation: intracellular signaling pathways Pober, Jordan S Arthritis Res Review CHAPTER SUMMARY: Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules. BioMed Central 2002 2002-05-09 /pmc/articles/PMC3240152/ /pubmed/12110129 http://dx.doi.org/10.1186/ar576 Text en Copyright ©2002 BioMed Central Ltd |
| spellingShingle | Review Pober, Jordan S Endothelial activation: intracellular signaling pathways |
| title | Endothelial activation: intracellular signaling pathways |
| title_full | Endothelial activation: intracellular signaling pathways |
| title_fullStr | Endothelial activation: intracellular signaling pathways |
| title_full_unstemmed | Endothelial activation: intracellular signaling pathways |
| title_short | Endothelial activation: intracellular signaling pathways |
| title_sort | endothelial activation: intracellular signaling pathways |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240152/ https://www.ncbi.nlm.nih.gov/pubmed/12110129 http://dx.doi.org/10.1186/ar576 |
| work_keys_str_mv | AT poberjordans endothelialactivationintracellularsignalingpathways |