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BRCA1 tumor suppression occurs via heterochromatin mediated silencing

Mutations in tumor suppressor BRCA1 lead to breast and/or ovarian cancer. Here we show that loss of BRCA1 in mice results in transcriptional derepression of the tandemly repeated satellite DNA. BRCA1 deficiency is accompanied by reduction of condensed DNA regions in the genome and loss of ubiquityla...

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Detalles Bibliográficos
Autores principales:	Zhu, Quan, Pao, Gerald M., Huynh, Alexis M., Suh, Hoonkyo, Tonnu, Nina, Nederlof, Petra, Gage, Fred H., Verma, Inder M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240576/ https://www.ncbi.nlm.nih.gov/pubmed/21901007 http://dx.doi.org/10.1038/nature10371

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