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HIF-1 Regulates Iron Homeostasis in Caenorhabditis elegans by Activation and Inhibition of Genes Involved in Iron Uptake and Storage

Caenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine. Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 a...

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Detalles Bibliográficos
Autores principales:	Romney, Steven Joshua, Newman, Ben S., Thacker, Colin, Leibold, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240588/ https://www.ncbi.nlm.nih.gov/pubmed/22194696 http://dx.doi.org/10.1371/journal.pgen.1002394

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