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Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil

The fluoropyrimidines 5-fluorouracil (5-FU) and FdUrd (5-fluorodeoxyuridine; floxuridine) are the backbone of chemotherapy regimens for colon cancer and other tumors. Despite their widespread use, it remains unclear how these agents kill tumor cells. Here, we have analyzed the checkpoint and DNA rep...

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Detalles Bibliográficos
Autores principales:	Geng, Liyi, Huehls, Amelia M., Wagner, Jill M., Huntoon, Catherine J., Karnitz, Larry M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240632/ https://www.ncbi.nlm.nih.gov/pubmed/22194930 http://dx.doi.org/10.1371/journal.pone.0028862

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