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Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C

Synthesis of nanosized particle of Ag-doped hydroxyapatite with antibacterial properties is in the great interest in the development of new biomedical applications. In this article, we propose a method for synthesized the Ag-doped nanocrystalline hydroxyapatite. A silver-doped nanocrystalline hydrox...

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Autores principales: Ciobanu, Carmen Steluta, Massuyeau, Florian, Constantin, Liliana Violeta, Predoi, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240665/
https://www.ncbi.nlm.nih.gov/pubmed/22136671
http://dx.doi.org/10.1186/1556-276X-6-613
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author Ciobanu, Carmen Steluta
Massuyeau, Florian
Constantin, Liliana Violeta
Predoi, Daniela
author_facet Ciobanu, Carmen Steluta
Massuyeau, Florian
Constantin, Liliana Violeta
Predoi, Daniela
author_sort Ciobanu, Carmen Steluta
collection PubMed
description Synthesis of nanosized particle of Ag-doped hydroxyapatite with antibacterial properties is in the great interest in the development of new biomedical applications. In this article, we propose a method for synthesized the Ag-doped nanocrystalline hydroxyapatite. A silver-doped nanocrystalline hydroxyapatite was synthesized at 100°C in deionized water. Other phase or impurities were not observed. Silver-doped hydroxyapatite nanoparticles (Ag:HAp) were performed by setting the atomic ratio of Ag/[Ag + Ca] at 20% and [Ca + Ag]/P as 1.67. The X-ray diffraction studies demonstrate that powders made by co-precipitation at 100°C exhibit the apatite characteristics with good crystal structure and no new phase or impurity is found. The scanning electron microscopy (SEM) observations suggest that these materials present a little different morphology, which reveals a homogeneous aspect of the synthesized particles for all samples. The presence of calcium (Ca), phosphor (P), oxygen (O), and silver (Ag) in the Ag:HAp is confirmed by energy dispersive X-ray (EDAX) analysis. FT-IR and FT-Raman spectroscopies revealed that the presence of the various vibrational modes corresponds to phosphates and hydroxyl groups. The strain of Staphylococcus aureus was used to evaluate the antibacterial activity of the Ca(10-x)Ag(x)(PO4)6(OH)2 (x = 0 and 0.2). In vitro bacterial adhesion study indicated a significant difference between HAp (x = 0) and Ag:HAp (x = 0.2). The Ag:Hap nanopowder showed higher inhibition.
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spelling pubmed-32406652011-12-19 Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C Ciobanu, Carmen Steluta Massuyeau, Florian Constantin, Liliana Violeta Predoi, Daniela Nanoscale Res Lett Nano Express Synthesis of nanosized particle of Ag-doped hydroxyapatite with antibacterial properties is in the great interest in the development of new biomedical applications. In this article, we propose a method for synthesized the Ag-doped nanocrystalline hydroxyapatite. A silver-doped nanocrystalline hydroxyapatite was synthesized at 100°C in deionized water. Other phase or impurities were not observed. Silver-doped hydroxyapatite nanoparticles (Ag:HAp) were performed by setting the atomic ratio of Ag/[Ag + Ca] at 20% and [Ca + Ag]/P as 1.67. The X-ray diffraction studies demonstrate that powders made by co-precipitation at 100°C exhibit the apatite characteristics with good crystal structure and no new phase or impurity is found. The scanning electron microscopy (SEM) observations suggest that these materials present a little different morphology, which reveals a homogeneous aspect of the synthesized particles for all samples. The presence of calcium (Ca), phosphor (P), oxygen (O), and silver (Ag) in the Ag:HAp is confirmed by energy dispersive X-ray (EDAX) analysis. FT-IR and FT-Raman spectroscopies revealed that the presence of the various vibrational modes corresponds to phosphates and hydroxyl groups. The strain of Staphylococcus aureus was used to evaluate the antibacterial activity of the Ca(10-x)Ag(x)(PO4)6(OH)2 (x = 0 and 0.2). In vitro bacterial adhesion study indicated a significant difference between HAp (x = 0) and Ag:HAp (x = 0.2). The Ag:Hap nanopowder showed higher inhibition. Springer 2011-12-03 /pmc/articles/PMC3240665/ /pubmed/22136671 http://dx.doi.org/10.1186/1556-276X-6-613 Text en Copyright ©2011 Ciobanu et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nano Express
Ciobanu, Carmen Steluta
Massuyeau, Florian
Constantin, Liliana Violeta
Predoi, Daniela
Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C
title Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C
title_full Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C
title_fullStr Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C
title_full_unstemmed Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C
title_short Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100°C
title_sort structural and physical properties of antibacterial ag-doped nano-hydroxyapatite synthesized at 100°c
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240665/
https://www.ncbi.nlm.nih.gov/pubmed/22136671
http://dx.doi.org/10.1186/1556-276X-6-613
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