Cargando…

Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease

BACKGROUND/AIMS: Studies concerning red cell distribution width (RDW) for use in the assessment of inflammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a marker of active disease in patients with IBD. METHODS: In total, 61 patients with ulcerative colitis (UC) and 56...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeşil, Atakan, Şenateş, Ebubekir, Bayoğlu, İbrahim Vedat, Erdem, Emrullah Düzgün, Demirtunç, Refik, Kurdaş Övünç, Ayşe Oya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Society of Pancreatobiliary Diseases 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240789/
https://www.ncbi.nlm.nih.gov/pubmed/22195244
http://dx.doi.org/10.5009/gnl.2011.5.4.460
_version_ 1782219474025316352
author Yeşil, Atakan
Şenateş, Ebubekir
Bayoğlu, İbrahim Vedat
Erdem, Emrullah Düzgün
Demirtunç, Refik
Kurdaş Övünç, Ayşe Oya
author_facet Yeşil, Atakan
Şenateş, Ebubekir
Bayoğlu, İbrahim Vedat
Erdem, Emrullah Düzgün
Demirtunç, Refik
Kurdaş Övünç, Ayşe Oya
author_sort Yeşil, Atakan
collection PubMed
description BACKGROUND/AIMS: Studies concerning red cell distribution width (RDW) for use in the assessment of inflammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a marker of active disease in patients with IBD. METHODS: In total, 61 patients with ulcerative colitis (UC) and 56 patients with Crohn's disease (CD) were enrolled in the study group, and 44 age- and-sex-matched healthy volunteers were included as the control group. A CD activity index >150 in patients with CD indicated active disease. Patients with moderate and severe disease based on the Truelove-Witts criteria were considered to have active UC. In addition to RDW, serum C-reactive protein levels, erythrocyte sedimentation rates, and platelet counts were measured. RESULTS: Twenty-nine (51.7%) patients with CD and 35 (57.4%) patients with UC had active disease. The RDW was significantly higher in patients with CD and UC than in controls (p<0.001 and p<0.001, respectively). A subgroup analysis indicated that for a RDW cut-off of 14%, the sensitivity for detecting active CD was 79%, and the specicity was 93% (area under curve [AUC], 0.935; p<0.001). RDW was the most sensitive and specific marker for active CD. However, it was not valid for UC, as the ESR at a cutoff of 15.5 mm/hr showed a sensitivity of 83% and a specicity of 76% (AUC, 0.817; p<0.001), whereas the RDW at a cutoff of 14% showed 17% sensitivity and 84% specicity for detecting active UC. CONCLUSIONS: RDW was elevated in IBD in comparison with healthy controls and increased markedly in active disease. RDW may be a sensitive and specific marker for determining active CD, whereas ESR is an important marker of active UC.
format Online
Article
Text
id pubmed-3240789
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Society of Pancreatobiliary Diseases
record_format MEDLINE/PubMed
spelling pubmed-32407892011-12-22 Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease Yeşil, Atakan Şenateş, Ebubekir Bayoğlu, İbrahim Vedat Erdem, Emrullah Düzgün Demirtunç, Refik Kurdaş Övünç, Ayşe Oya Gut Liver Original Article BACKGROUND/AIMS: Studies concerning red cell distribution width (RDW) for use in the assessment of inflammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a marker of active disease in patients with IBD. METHODS: In total, 61 patients with ulcerative colitis (UC) and 56 patients with Crohn's disease (CD) were enrolled in the study group, and 44 age- and-sex-matched healthy volunteers were included as the control group. A CD activity index >150 in patients with CD indicated active disease. Patients with moderate and severe disease based on the Truelove-Witts criteria were considered to have active UC. In addition to RDW, serum C-reactive protein levels, erythrocyte sedimentation rates, and platelet counts were measured. RESULTS: Twenty-nine (51.7%) patients with CD and 35 (57.4%) patients with UC had active disease. The RDW was significantly higher in patients with CD and UC than in controls (p<0.001 and p<0.001, respectively). A subgroup analysis indicated that for a RDW cut-off of 14%, the sensitivity for detecting active CD was 79%, and the specicity was 93% (area under curve [AUC], 0.935; p<0.001). RDW was the most sensitive and specific marker for active CD. However, it was not valid for UC, as the ESR at a cutoff of 15.5 mm/hr showed a sensitivity of 83% and a specicity of 76% (AUC, 0.817; p<0.001), whereas the RDW at a cutoff of 14% showed 17% sensitivity and 84% specicity for detecting active UC. CONCLUSIONS: RDW was elevated in IBD in comparison with healthy controls and increased markedly in active disease. RDW may be a sensitive and specific marker for determining active CD, whereas ESR is an important marker of active UC. The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Society of Pancreatobiliary Diseases 2011-12 2011-11-21 /pmc/articles/PMC3240789/ /pubmed/22195244 http://dx.doi.org/10.5009/gnl.2011.5.4.460 Text en Copyright © 2011 The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, Korean Association for the Study of the Liver and Korean Society of Pancreatobiliary Diseases http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yeşil, Atakan
Şenateş, Ebubekir
Bayoğlu, İbrahim Vedat
Erdem, Emrullah Düzgün
Demirtunç, Refik
Kurdaş Övünç, Ayşe Oya
Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease
title Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease
title_full Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease
title_fullStr Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease
title_full_unstemmed Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease
title_short Red Cell Distribution Width: A Novel Marker of Activity in Inflammatory Bowel Disease
title_sort red cell distribution width: a novel marker of activity in inflammatory bowel disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240789/
https://www.ncbi.nlm.nih.gov/pubmed/22195244
http://dx.doi.org/10.5009/gnl.2011.5.4.460
work_keys_str_mv AT yesilatakan redcelldistributionwidthanovelmarkerofactivityininflammatoryboweldisease
AT senatesebubekir redcelldistributionwidthanovelmarkerofactivityininflammatoryboweldisease
AT bayogluibrahimvedat redcelldistributionwidthanovelmarkerofactivityininflammatoryboweldisease
AT erdememrullahduzgun redcelldistributionwidthanovelmarkerofactivityininflammatoryboweldisease
AT demirtuncrefik redcelldistributionwidthanovelmarkerofactivityininflammatoryboweldisease
AT kurdasovuncayseoya redcelldistributionwidthanovelmarkerofactivityininflammatoryboweldisease