Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Two promoters, 1A and 1B, have been recognized in APC, and 1B is thought to have a minor role in the regulation of the gene. We have identified a novel deletion encompassing half of thi...

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Detalles Bibliográficos
Autores principales: Rohlin, A, Engwall, Y, Fritzell, K, Göransson, K, Bergsten, A, Einbeigi, Z, Nilbert, M, Karlsson, P, Björk, J, Nordling, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240859/
https://www.ncbi.nlm.nih.gov/pubmed/21643010
http://dx.doi.org/10.1038/onc.2011.201

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