Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

BACKGROUND: The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately, results with N-terminal inhibitors from initial clinical trials have been disappoi...

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Detalles Bibliográficos
Autores principales: Eskew, Jeffery D, Sadikot, Takrima, Morales, Pedro, Duren, Alicia, Dunwiddie, Irene, Swink, Megan, Zhang, Xiaoying, Hembruff, Stacey, Donnelly, Alison, Rajewski, Roger A, Blagg, Brian SJ, Manjarrez, Jacob R, Matts, Robert L, Holzbeierlein, Jeffrey M, Vielhauer, George A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240935/
https://www.ncbi.nlm.nih.gov/pubmed/22039910
http://dx.doi.org/10.1186/1471-2407-11-468

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