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QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study

OBJECTIVE: Our aim was to assess whether severe hypoglycemic attacks were cross-sectionally associated with abnormalities of the QTc interval in type 1 diabetic patients. RESEARCH DESIGN AND METHODS: The study included 3,248 type 1 diabetic patients from the EURODIAB IDDM Complications Study. Severe...

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Autores principales: Gruden, Gabriella, Giunti, Sara, Barutta, Federica, Chaturvedi, Nish, Witte, Daniel R., Tricarico, Marinella, Fuller, John H., Cavallo Perin, Paolo, Bruno, Graziella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241323/
https://www.ncbi.nlm.nih.gov/pubmed/22124713
http://dx.doi.org/10.2337/dc11-1739
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author Gruden, Gabriella
Giunti, Sara
Barutta, Federica
Chaturvedi, Nish
Witte, Daniel R.
Tricarico, Marinella
Fuller, John H.
Cavallo Perin, Paolo
Bruno, Graziella
author_facet Gruden, Gabriella
Giunti, Sara
Barutta, Federica
Chaturvedi, Nish
Witte, Daniel R.
Tricarico, Marinella
Fuller, John H.
Cavallo Perin, Paolo
Bruno, Graziella
author_sort Gruden, Gabriella
collection PubMed
description OBJECTIVE: Our aim was to assess whether severe hypoglycemic attacks were cross-sectionally associated with abnormalities of the QTc interval in type 1 diabetic patients. RESEARCH DESIGN AND METHODS: The study included 3,248 type 1 diabetic patients from the EURODIAB IDDM Complications Study. Severe hypoglycemia was defined as an attack serious enough to require the help of another person. A corrected QTc interval (QTc) >0.44 s was considered abnormally prolonged. RESULTS: Nineteen percent of patients declared one to two attacks, and 13.2% of patients had three or more attacks. Prevalence of QTc prolongation was greater in patients who experienced three or more hypoglycemic attacks. Logistic regression analysis showed that the frequency of severe hypoglycemia was independently associated with QTc prolongation, even after adjustment for diabetes complications, including autonomic neuropathy (odds ratio 1.27, 95% CI 1.02–1.58). CONCLUSIONS: We have provided evidence that severe hypoglycemic attacks are independently associated with a prolonged QTc interval in type 1 diabetic patients from the EURODIAB IDDM Complications Study.
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spelling pubmed-32413232013-01-01 QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study Gruden, Gabriella Giunti, Sara Barutta, Federica Chaturvedi, Nish Witte, Daniel R. Tricarico, Marinella Fuller, John H. Cavallo Perin, Paolo Bruno, Graziella Diabetes Care Original Research OBJECTIVE: Our aim was to assess whether severe hypoglycemic attacks were cross-sectionally associated with abnormalities of the QTc interval in type 1 diabetic patients. RESEARCH DESIGN AND METHODS: The study included 3,248 type 1 diabetic patients from the EURODIAB IDDM Complications Study. Severe hypoglycemia was defined as an attack serious enough to require the help of another person. A corrected QTc interval (QTc) >0.44 s was considered abnormally prolonged. RESULTS: Nineteen percent of patients declared one to two attacks, and 13.2% of patients had three or more attacks. Prevalence of QTc prolongation was greater in patients who experienced three or more hypoglycemic attacks. Logistic regression analysis showed that the frequency of severe hypoglycemia was independently associated with QTc prolongation, even after adjustment for diabetes complications, including autonomic neuropathy (odds ratio 1.27, 95% CI 1.02–1.58). CONCLUSIONS: We have provided evidence that severe hypoglycemic attacks are independently associated with a prolonged QTc interval in type 1 diabetic patients from the EURODIAB IDDM Complications Study. American Diabetes Association 2012-01 2011-12-09 /pmc/articles/PMC3241323/ /pubmed/22124713 http://dx.doi.org/10.2337/dc11-1739 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Gruden, Gabriella
Giunti, Sara
Barutta, Federica
Chaturvedi, Nish
Witte, Daniel R.
Tricarico, Marinella
Fuller, John H.
Cavallo Perin, Paolo
Bruno, Graziella
QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study
title QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study
title_full QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study
title_fullStr QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study
title_full_unstemmed QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study
title_short QTc Interval Prolongation Is Independently Associated With Severe Hypoglycemic Attacks in Type 1 Diabetes From the EURODIAB IDDM Complications Study
title_sort qtc interval prolongation is independently associated with severe hypoglycemic attacks in type 1 diabetes from the eurodiab iddm complications study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241323/
https://www.ncbi.nlm.nih.gov/pubmed/22124713
http://dx.doi.org/10.2337/dc11-1739
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