Cargando…

Synthesis and Properties of Molecular Probes for the Rescue Site on Mutant Cystic Fibrosis Transmembrane Conductance Regulator

[Image: see text] Cystic fibrosis is a genetic disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In vitro experiments have demonstrated that 4-methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol (VRT-532, 1) is able to partially restore the fun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alkhouri, Bashar, Denning, Robert A., Kim Chiaw, Patrick, Eckford, Paul D. W., Yu, Wilson, Li, Canhui, Bogojeski, Jovanka J., Bear, Christine E., Viirre, Russell D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241338/ https://www.ncbi.nlm.nih.gov/pubmed/22074181 http://dx.doi.org/10.1021/jm201335c

Ejemplares similares

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface
por: Chin, Stephanie, et al.
Publicado: (2017)

A transistor model for the cystic fibrosis transmembrane conductance regulator
por: Hunt, William D., et al.
Publicado: (2023)

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor
por: Broadbent, Steven D., et al.
Publicado: (2014)

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator
por: Proctor, Elizabeth A., et al.
Publicado: (2015)

Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator
por: Laselva, Onofrio, et al.
Publicado: (2021)

Glycosylation and the cystic fibrosis transmembrane conductance regulator
por: Scanlin, Thomas F, et al.
Publicado: (2001)

Where Is the Cystic Fibrosis Transmembrane Conductance Regulator?
por: Barbry, Pascal, et al.
Publicado: (2021)

Halide Permeation in Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels
por: Tabcharani, Joseph A., et al.
Publicado: (1997)

Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
por: Chin, Stephanie, et al.
Publicado: (2019)

Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives
por: Schmidt, Béla Z, et al.
Publicado: (2016)

The Extrapulmonary Effects of Cystic Fibrosis Transmembrane Conductance Regulator Modulators in Cystic Fibrosis
por: Sergeev, Valentine, et al.
Publicado: (2020)

Acquired cystic fibrosis transmembrane conductance regulator dysfunction
por: Banks, Catherine, et al.
Publicado: (2018)

Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator
por: Villamizar, Olga, et al.
Publicado: (2019)

Permeability of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels to Polyatomic Anions
por: Linsdell, Paul, et al.
Publicado: (1997)

Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains
por: Csanády, László, et al.
Publicado: (2000)

A Proteomic Survey of the Cystic Fibrosis Transmembrane Conductance Regulator Surfaceome
por: Iazzi, Melissa, et al.
Publicado: (2023)

Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore
por: Wang, Wuyang, et al.
Publicado: (2011)

Cystic fibrosis transmembrane conductance regulator mutations at a referral center for cystic fibrosis
por: Coutinho, Cyntia Arivabeni de Araújo Correia, et al.
Publicado: (2013)

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity
por: Malik, Firhan A., et al.
Publicado: (2015)

666 Ivacaftor boosts cystic fibrosis transmembrane conductance regulator–mediated nasal potential difference in cystic fibrosis transmembrane conductance regulator knockout mice treated with human cystic fibrosis transmembrane conductance regulator messenger ribonucleic acid lipid nanoparticle
por: Mukherjee, A., et al.
Publicado: (2022)

Distinct proteostasis states drive pharmacologic chaperone susceptibility for cystic fibrosis transmembrane conductance regulator misfolding mutants
por: McDonald, Eli Fritz, et al.
Publicado: (2022)

A protocol for identifying the binding sites of small molecules on the cystic fibrosis transmembrane conductance regulator (CFTR) protein
por: Laselva, Onofrio, et al.
Publicado: (2022)

The cystic fibrosis transmembrane conductance regulator (CFTR) and its stability
por: Meng, Xin, et al.
Publicado: (2016)

Cystic Fibrosis Transmembrane Conductance Regulator Folding Mutations Reveal Differences in Corrector Efficacy Linked to Increases in Immature Cystic Fibrosis Transmembrane Conductance Regulator Expression
por: Peters, Kathryn W., et al.
Publicado: (2021)

Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator
por: Kleizen, Bertrand, et al.
Publicado: (2023)

Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy: A Review for the Otolaryngologist
por: Lee, Saangyoung E., et al.
Publicado: (2020)

Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator
por: Bartoszewski, Rafal, et al.
Publicado: (2016)

Cystic fibrosis transmembrane conductance regulator function in patients with chronic pancreatitis
por: Schlosser, Tobias, et al.
Publicado: (2022)

Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia
Publicado: (1992)

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis
por: Fukuda, Ryosuke, et al.
Publicado: (2020)

A Developmental Role of the Cystic Fibrosis Transmembrane Conductance Regulator in Cystic Fibrosis Lung Disease Pathogenesis
por: Huang, Elena N., et al.
Publicado: (2021)

Anti-Inflammatory Influences of Cystic Fibrosis Transmembrane Conductance Regulator Drugs on Lung Inflammation in Cystic Fibrosis
por: Harwood, Kiera H., et al.
Publicado: (2021)

A New Era for Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator Modulator Trials in Infants
por: Wainwright, Claire E.
Publicado: (2022)

Lung Inflammatory Genes in Cystic Fibrosis and Their Relevance to Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapies
por: Carbone, Annalucia, et al.
Publicado: (2023)

Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene
por: Sosnay, Patrick R, et al.
Publicado: (2013)

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS
por: Corradi, Valentina, et al.
Publicado: (2015)

Cystic Fibrosis Transmembrane Conductance Regulator: Physical Basis for Lyotropic Anion Selectivity Patterns
por: Smith, Stephen S., et al.
Publicado: (1999)

Epithelial IgG and its relationship to the loss of F508 in the common mutant form of the cystic fibrosis transmembrane conductance regulator
por: Treharne, Kate J., et al.
Publicado: (2009)

Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs
por: Meyerholz, David K., et al.
Publicado: (2018)

Commentary Cystic Fibrosis Transmembrane Conductance Regulator : Permeant Ions Find the Pore
por: Dawson, David C., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_t0kmjv8ncj7gjetiqnkbhvkcr9