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Synthesis and Properties of Molecular Probes for the Rescue Site on Mutant Cystic Fibrosis Transmembrane Conductance Regulator

[Image: see text] Cystic fibrosis is a genetic disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In vitro experiments have demonstrated that 4-methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol (VRT-532, 1) is able to partially restore the fun...

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Detalles Bibliográficos
Autores principales:	Alkhouri, Bashar, Denning, Robert A., Kim Chiaw, Patrick, Eckford, Paul D. W., Yu, Wilson, Li, Canhui, Bogojeski, Jovanka J., Bear, Christine E., Viirre, Russell D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241338/ https://www.ncbi.nlm.nih.gov/pubmed/22074181 http://dx.doi.org/10.1021/jm201335c

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