Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of th...

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Detalles Bibliográficos
Autores principales: Loewith, Robbie, Hall, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2011
Materias:
YeastBook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241408/
https://www.ncbi.nlm.nih.gov/pubmed/22174183
http://dx.doi.org/10.1534/genetics.111.133363
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author Loewith, Robbie
Hall, Michael N.
author_facet Loewith, Robbie
Hall, Michael N.
author_sort Loewith, Robbie
collection PubMed
description TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.
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spelling pubmed-32414082012-01-24 Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control Loewith, Robbie Hall, Michael N. Genetics YeastBook TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae. Genetics Society of America 2011-12 /pmc/articles/PMC3241408/ /pubmed/22174183 http://dx.doi.org/10.1534/genetics.111.133363 Text en Copyright © 2011 by the Genetics Society of America Available freely online through the author-supported open access option.
spellingShingle YeastBook
Loewith, Robbie
Hall, Michael N.
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
title Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
title_full Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
title_fullStr Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
title_full_unstemmed Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
title_short Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
title_sort target of rapamycin (tor) in nutrient signaling and growth control
topic YeastBook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241408/
https://www.ncbi.nlm.nih.gov/pubmed/22174183
http://dx.doi.org/10.1534/genetics.111.133363
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