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The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding

SimR, a TetR-family transcriptional regulator (TFR), controls the export of simocyclinone, a potent DNA gyrase inhibitor made by Streptomyces antibioticus. Simocyclinone is exported by a specific efflux pump, SimX and the transcription of simX is repressed by SimR, which binds to two operators in th...

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Detalles Bibliográficos
Autores principales:	Le, Tung B. K., Schumacher, Maria A., Lawson, David M., Brennan, Richard G., Buttner, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241653/ https://www.ncbi.nlm.nih.gov/pubmed/21835774 http://dx.doi.org/10.1093/nar/gkr640

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