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The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis

Mitochondrial DNA replication is performed by a simple machinery, containing the TWINKLE DNA helicase, a single-stranded DNA-binding protein, and the mitochondrial DNA polymerase γ. In addition, mitochondrial RNA polymerase is required for primer formation at the origins of DNA replication. TWINKLE...

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Detalles Bibliográficos
Autores principales:	Jemt, Elisabeth, Farge, Géraldine, Bäckström, Stefan, Holmlund, Teresa, Gustafsson, Claes M., Falkenberg, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241658/ https://www.ncbi.nlm.nih.gov/pubmed/21840902 http://dx.doi.org/10.1093/nar/gkr653

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