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The SRSF1 linker induces semi-conservative ESE binding by cooperating with the RRMs

SR proteins promote spliceosome formation by recognizing exonic splicing enhancers (ESEs) during pre-mRNA splicing. Each SR protein binds diverse ESEs using strategies that are yet to be elucidated. Here, we show that the RNA-binding domain (RBD) of SRSF1 optimally binds to decameric purine rich ESE...

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Detalles Bibliográficos
Autores principales:	Cho, Suhyung, Hoang, Amy, Chakrabarti, Sutapa, Huynh, Nhat, Huang, De-Bin, Ghosh, Gourisankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241662/ https://www.ncbi.nlm.nih.gov/pubmed/21852328 http://dx.doi.org/10.1093/nar/gkr663

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