Lipid traffic: Osh4p makes an unexpected exchange

A new study in this issue (De Saint-Jean et al. 2011. J. Cell Biol. http://dx.doi.org/jcb.201104062) reveals that the sterol transfer protein Osh4p can also transport the signaling phospholipid phosphatidylinositol 4-phosphate (PI(4)P), which binds to the same site in Osh4p as sterol. This finding h...

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Detalles Bibliográficos
Autor principal: Levine, Tim P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241729/
https://www.ncbi.nlm.nih.gov/pubmed/22162132
http://dx.doi.org/10.1083/jcb.201111074
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author Levine, Tim P.
author_facet Levine, Tim P.
author_sort Levine, Tim P.
collection PubMed
description A new study in this issue (De Saint-Jean et al. 2011. J. Cell Biol. http://dx.doi.org/jcb.201104062) reveals that the sterol transfer protein Osh4p can also transport the signaling phospholipid phosphatidylinositol 4-phosphate (PI(4)P), which binds to the same site in Osh4p as sterol. This finding helps explain some previously published studies and also indicates that lipid/sterol exchange could contribute to establishing a sterol gradient in cells.
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spelling pubmed-32417292012-06-12 Lipid traffic: Osh4p makes an unexpected exchange Levine, Tim P. J Cell Biol Reviews A new study in this issue (De Saint-Jean et al. 2011. J. Cell Biol. http://dx.doi.org/jcb.201104062) reveals that the sterol transfer protein Osh4p can also transport the signaling phospholipid phosphatidylinositol 4-phosphate (PI(4)P), which binds to the same site in Osh4p as sterol. This finding helps explain some previously published studies and also indicates that lipid/sterol exchange could contribute to establishing a sterol gradient in cells. The Rockefeller University Press 2011-12-12 /pmc/articles/PMC3241729/ /pubmed/22162132 http://dx.doi.org/10.1083/jcb.201111074 Text en © 2011 Levine This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Levine, Tim P.
Lipid traffic: Osh4p makes an unexpected exchange
title Lipid traffic: Osh4p makes an unexpected exchange
title_full Lipid traffic: Osh4p makes an unexpected exchange
title_fullStr Lipid traffic: Osh4p makes an unexpected exchange
title_full_unstemmed Lipid traffic: Osh4p makes an unexpected exchange
title_short Lipid traffic: Osh4p makes an unexpected exchange
title_sort lipid traffic: osh4p makes an unexpected exchange
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241729/
https://www.ncbi.nlm.nih.gov/pubmed/22162132
http://dx.doi.org/10.1083/jcb.201111074
work_keys_str_mv AT levinetimp lipidtrafficosh4pmakesanunexpectedexchange

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