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A Neutral Diphosphate Mimic Crosslinks the Active Site of Human O-GlcNAc Transferase

Glycosyltransferases (Gtfs) catalyze the formation of a diverse array of glycoconjugates. Small molecule inhibitors to manipulate Gtf activity in cells have long been sought as tools to understand Gtf function. Success has been limited due to challenges in designing inhibitors that mimic the negativ...

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Detalles Bibliográficos
Autores principales:	Jiang, Jiaoyang, Lazarus, Michael B., Pasquina, Lincoln, Sliz, Piotr, Walker, Suzanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241908/ https://www.ncbi.nlm.nih.gov/pubmed/22082911 http://dx.doi.org/10.1038/nchembio.711

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