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Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats
Spigelia anthelmia Linn is used as a herb and is a common annual weed of cultivation in open re-growths, on unused land in towns as well as on road sides. The plant can grow to approximately 30 cm in height. The aim of this study was to screen extracts of Spigelia anthelmia for their anthelmintic ac...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Veterinary Science
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242121/ https://www.ncbi.nlm.nih.gov/pubmed/16871016 http://dx.doi.org/10.4142/jvs.2006.7.3.229 |
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author | Jegede, Olorunfemi Cornelius Ajanusi, Joseph Ologunja Adaudi, Ambrose. O. Agbede, Rowland I. S. |
author_facet | Jegede, Olorunfemi Cornelius Ajanusi, Joseph Ologunja Adaudi, Ambrose. O. Agbede, Rowland I. S. |
author_sort | Jegede, Olorunfemi Cornelius |
collection | PubMed |
description | Spigelia anthelmia Linn is used as a herb and is a common annual weed of cultivation in open re-growths, on unused land in towns as well as on road sides. The plant can grow to approximately 30 cm in height. The aim of this study was to screen extracts of Spigelia anthelmia for their anthelmintic activity against an experimental Nippostrongylus braziliensis infection in rats. Acute oral toxicity occurred at a dose of 1,140mg/kg, while anthelmintic trials against Nippostrongylus braziliensis in rats using the aqueous fraction showed a progressive decrease in worm count with increasing dose (10, 13, 16, 20 and 25 mg per kg body weight) (p < 0.05). At 25 mg per kg body weight, the worm count was significantly lower than that at 10mg per kg body weight (p < 0.05). |
format | Online Article Text |
id | pubmed-3242121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32421212011-12-22 Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats Jegede, Olorunfemi Cornelius Ajanusi, Joseph Ologunja Adaudi, Ambrose. O. Agbede, Rowland I. S. J Vet Sci Original Article Spigelia anthelmia Linn is used as a herb and is a common annual weed of cultivation in open re-growths, on unused land in towns as well as on road sides. The plant can grow to approximately 30 cm in height. The aim of this study was to screen extracts of Spigelia anthelmia for their anthelmintic activity against an experimental Nippostrongylus braziliensis infection in rats. Acute oral toxicity occurred at a dose of 1,140mg/kg, while anthelmintic trials against Nippostrongylus braziliensis in rats using the aqueous fraction showed a progressive decrease in worm count with increasing dose (10, 13, 16, 20 and 25 mg per kg body weight) (p < 0.05). At 25 mg per kg body weight, the worm count was significantly lower than that at 10mg per kg body weight (p < 0.05). The Korean Society of Veterinary Science 2006-09 2006-09-30 /pmc/articles/PMC3242121/ /pubmed/16871016 http://dx.doi.org/10.4142/jvs.2006.7.3.229 Text en Copyright © 2006 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jegede, Olorunfemi Cornelius Ajanusi, Joseph Ologunja Adaudi, Ambrose. O. Agbede, Rowland I. S. Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats |
title | Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats |
title_full | Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats |
title_fullStr | Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats |
title_full_unstemmed | Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats |
title_short | Anthelmintic efficacy of extracts of Spigelia anthelmia Linn on experimental Nippostrongylus braziliensis in rats |
title_sort | anthelmintic efficacy of extracts of spigelia anthelmia linn on experimental nippostrongylus braziliensis in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242121/ https://www.ncbi.nlm.nih.gov/pubmed/16871016 http://dx.doi.org/10.4142/jvs.2006.7.3.229 |
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