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Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An essential feature of AD pathology is the presence of BACE1 (β-site amyloid precursor protein-cleaving enzyme 1), which regulates production...

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Detalles Bibliográficos
Autores principales:	Meakin, Paul J., Harper, Alex J., Hamilton, D. Lee, Gallagher, Jennifer, McNeilly, Alison D., Burgess, Laura A., Vaanholt, Lobke M., Bannon, Kirsten A., Latcham, Judy, Hussain, Ishrut, Speakman, John R., Howlett, David R., Ashford, Michael L.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242510/ https://www.ncbi.nlm.nih.gov/pubmed/21880018 http://dx.doi.org/10.1042/BJ20110512

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