Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage

Elevated MPO (myeloperoxidase) levels are associated with multiple human inflammatory pathologies. MPO catalyses the oxidation of Cl(−), Br(−) and SCN(−) by H(2)O(2) to generate the powerful oxidants hypochlorous acid (HOCl), hypobromous acid (HOBr) and hypothiocyanous acid (HOSCN) respectively. The...

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Detalles Bibliográficos
Autores principales: Skaff, Ojia, Pattison, David I., Morgan, Philip E., Bachana, Rushad, Jain, Vimal K., Priyadarsini, K. Indira, Davies, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242511/
https://www.ncbi.nlm.nih.gov/pubmed/21892922
http://dx.doi.org/10.1042/BJ20101762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242511/
https://www.ncbi.nlm.nih.gov/pubmed/21892922
http://dx.doi.org/10.1042/BJ20101762

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