Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production

BACKGROUND: Although matrix metalloproteinases (MMPs) are implicated in tumourigenesis and cancer progression, the role of MMP-13 in melanoma cell metastases is poorly understood. METHODS: Lung metastases of mouse melanoma B16BL6 cells were analysed in MMP-13 knockout (KO) and wild-type (WT) mice af...

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Detalles Bibliográficos
Autores principales: Fukuda, H, Mochizuki, S, Abe, H, Okano, H J, Hara-Miyauchi, C, Okano, H, Yamaguchi, N, Nakayama, M, D'Armiento, J, Okada, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242531/
https://www.ncbi.nlm.nih.gov/pubmed/22015555
http://dx.doi.org/10.1038/bjc.2011.431

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