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Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network
BACKGROUND: Ascertainment of cases and disease classification is an acknowledged problem for epidemiological research into haematological malignancies. METHODS: The Haematological Malignancy Research Network comprises an ongoing population-based patient cohort. All diagnoses (paediatric and adult) a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242607/ https://www.ncbi.nlm.nih.gov/pubmed/22045184 http://dx.doi.org/10.1038/bjc.2011.450 |
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author | Smith, A Howell, D Patmore, R Jack, A Roman, E |
author_facet | Smith, A Howell, D Patmore, R Jack, A Roman, E |
author_sort | Smith, A |
collection | PubMed |
description | BACKGROUND: Ascertainment of cases and disease classification is an acknowledged problem for epidemiological research into haematological malignancies. METHODS: The Haematological Malignancy Research Network comprises an ongoing population-based patient cohort. All diagnoses (paediatric and adult) across two UK Cancer Networks (population 3.6 million, >2000 diagnoses annually, socio-demographically representative of the UK) are made by an integrated haematopathology laboratory. Diagnostics, prognostics, and treatment are recorded to clinical trial standards, and socio-demographic measures are routinely obtained. RESULTS: A total of 10 729 haematological malignancies (myeloid=2706, lymphoid=8023) were diagnosed over the 5 years, that is, from 2004 to 2009. Descriptive data (age, sex, and deprivation), sex-specific age-standardised (European population) rates, and estimated UK frequencies are presented for 24 sub-types. The age of patients ranged from 4 weeks to 99 years (median 70.6 years), and the male rate was more than double the female rate for several myeloid and lymphoid sub-types, this difference being evident in both children and adults. No relationship with deprivation was detected. CONCLUSION: Accurate population-based data on haematological malignancies can be collected to the standard required to deliver reproducible results that can be extrapolated to national populations. Our analyses emphasise the importance of gender and age as disease determinants, and suggest that aetiological investigations that focus on socio-economic factors are unlikely to be rewarding. |
format | Online Article Text |
id | pubmed-3242607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-32426072012-11-22 Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network Smith, A Howell, D Patmore, R Jack, A Roman, E Br J Cancer Clinical Study BACKGROUND: Ascertainment of cases and disease classification is an acknowledged problem for epidemiological research into haematological malignancies. METHODS: The Haematological Malignancy Research Network comprises an ongoing population-based patient cohort. All diagnoses (paediatric and adult) across two UK Cancer Networks (population 3.6 million, >2000 diagnoses annually, socio-demographically representative of the UK) are made by an integrated haematopathology laboratory. Diagnostics, prognostics, and treatment are recorded to clinical trial standards, and socio-demographic measures are routinely obtained. RESULTS: A total of 10 729 haematological malignancies (myeloid=2706, lymphoid=8023) were diagnosed over the 5 years, that is, from 2004 to 2009. Descriptive data (age, sex, and deprivation), sex-specific age-standardised (European population) rates, and estimated UK frequencies are presented for 24 sub-types. The age of patients ranged from 4 weeks to 99 years (median 70.6 years), and the male rate was more than double the female rate for several myeloid and lymphoid sub-types, this difference being evident in both children and adults. No relationship with deprivation was detected. CONCLUSION: Accurate population-based data on haematological malignancies can be collected to the standard required to deliver reproducible results that can be extrapolated to national populations. Our analyses emphasise the importance of gender and age as disease determinants, and suggest that aetiological investigations that focus on socio-economic factors are unlikely to be rewarding. Nature Publishing Group 2011-11-22 2011-11-01 /pmc/articles/PMC3242607/ /pubmed/22045184 http://dx.doi.org/10.1038/bjc.2011.450 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Study Smith, A Howell, D Patmore, R Jack, A Roman, E Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network |
title | Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network |
title_full | Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network |
title_fullStr | Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network |
title_full_unstemmed | Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network |
title_short | Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network |
title_sort | incidence of haematological malignancy by sub-type: a report from the haematological malignancy research network |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242607/ https://www.ncbi.nlm.nih.gov/pubmed/22045184 http://dx.doi.org/10.1038/bjc.2011.450 |
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