Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

Lipid nanoparticles (LNPs) are currently the most effective in vivo delivery systems for silencing target genes in hepatocytes employing small interfering RNA. Antigen-presenting cells (APCs) are also potential targets for LNP siRNA. We examined the uptake, intracellular trafficking, and gene silenc...

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Detalles Bibliográficos
Autores principales: Basha, Genc, Novobrantseva, Tatiana I, Rosin, Nicole, Tam, Yuen Yi C, Hafez, Ismail M, Wong, Matthew K, Sugo, Tsukasa, Ruda, Vera M, Qin, June, Klebanov, Boris, Ciufolini, Marco, Akinc, Akin, Tam, Ying K, Hope, Michael J, Cullis, Pieter R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242662/
https://www.ncbi.nlm.nih.gov/pubmed/21971424
http://dx.doi.org/10.1038/mt.2011.190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242662/
https://www.ncbi.nlm.nih.gov/pubmed/21971424
http://dx.doi.org/10.1038/mt.2011.190

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