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Chromatin Remodeling, Cell Proliferation and Cell Death in Valproic Acid-Treated HeLa Cells

BACKGROUND: Valproic acid (VPA) is a potent anticonvulsant that inhibits histone deacetylases. Because of this inhibitory action, we investigated whether VPA would affect chromatin supraorganization, mitotic indices and the frequency of chromosome abnormalities and cell death in HeLa cells. METHODOL...

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Detalles Bibliográficos
Autores principales:	Felisbino, Marina Barreto, Tamashiro, Wirla M. S. C., Mello, Maria Luiza S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242782/ https://www.ncbi.nlm.nih.gov/pubmed/22206001 http://dx.doi.org/10.1371/journal.pone.0029144

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