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Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli

Odors are rarely composed of a single compound, but rather contain a large and complex variety of chemical components. Often, these mixtures are perceived as having unique qualities that can be quite different than the combination of their components. In many cases, a majority of the components of a...

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Autor principal: Fletcher, Max L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243692/
https://www.ncbi.nlm.nih.gov/pubmed/22206012
http://dx.doi.org/10.1371/journal.pone.0029360
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author Fletcher, Max L.
author_facet Fletcher, Max L.
author_sort Fletcher, Max L.
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description Odors are rarely composed of a single compound, but rather contain a large and complex variety of chemical components. Often, these mixtures are perceived as having unique qualities that can be quite different than the combination of their components. In many cases, a majority of the components of a mixture cannot be individually identified. This synthetic processing of odor information suggests that individual component representations of the mixture must interact somewhere along the olfactory pathway. The anatomical nature of sensory neuron input into segregated glomeruli with the bulb suggests that initial input of odor information into the bulb is analytic. However, a large network of interneurons within the olfactory bulb could allow for mixture interactions via mechanisms such as lateral inhibition. Currently in mammals, it is unclear if postsynaptic mitral/tufted cell glomerular mixture responses reflect the analytical mixture input, or provide the initial basis for synthetic processing with the olfactory system. To address this, olfactory bulb glomerular binary mixture representations were compared to representations of each component using transgenic mice expressing the calcium indicator G-CaMP2 in olfactory bulb mitral/tufted cells. Overall, dorsal surface mixture representations showed little mixture interaction and often appeared as a simple combination of the component representations. Based on this, it is concluded that dorsal surface glomerular mixture representations remain largely analytical with nearly all component information preserved.
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spelling pubmed-32436922011-12-28 Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli Fletcher, Max L. PLoS One Research Article Odors are rarely composed of a single compound, but rather contain a large and complex variety of chemical components. Often, these mixtures are perceived as having unique qualities that can be quite different than the combination of their components. In many cases, a majority of the components of a mixture cannot be individually identified. This synthetic processing of odor information suggests that individual component representations of the mixture must interact somewhere along the olfactory pathway. The anatomical nature of sensory neuron input into segregated glomeruli with the bulb suggests that initial input of odor information into the bulb is analytic. However, a large network of interneurons within the olfactory bulb could allow for mixture interactions via mechanisms such as lateral inhibition. Currently in mammals, it is unclear if postsynaptic mitral/tufted cell glomerular mixture responses reflect the analytical mixture input, or provide the initial basis for synthetic processing with the olfactory system. To address this, olfactory bulb glomerular binary mixture representations were compared to representations of each component using transgenic mice expressing the calcium indicator G-CaMP2 in olfactory bulb mitral/tufted cells. Overall, dorsal surface mixture representations showed little mixture interaction and often appeared as a simple combination of the component representations. Based on this, it is concluded that dorsal surface glomerular mixture representations remain largely analytical with nearly all component information preserved. Public Library of Science 2011-12-20 /pmc/articles/PMC3243692/ /pubmed/22206012 http://dx.doi.org/10.1371/journal.pone.0029360 Text en Max L. Fletcher. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Fletcher, Max L.
Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli
title Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli
title_full Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli
title_fullStr Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli
title_full_unstemmed Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli
title_short Analytical Processing of Binary Mixture Information by Olfactory Bulb Glomeruli
title_sort analytical processing of binary mixture information by olfactory bulb glomeruli
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243692/
https://www.ncbi.nlm.nih.gov/pubmed/22206012
http://dx.doi.org/10.1371/journal.pone.0029360
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