Integrated Dataset of Screening Hits against Multiple Neglected Disease Pathogens

New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these h...

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Detalles Bibliográficos
Autores principales: Nwaka, Solomon, Besson, Dominique, Ramirez, Bernadette, Maes, Louis, Matheeussen, An, Bickle, Quentin, Mansour, Nuha R., Yousif, Fouad, Townson, Simon, Gokool, Suzanne, Cho-Ngwa, Fidelis, Samje, Moses, Misra-Bhattacharya, Shailja, Murthy, P. K., Fakorede, Foluke, Paris, Jean-Marc, Yeates, Clive, Ridley, Robert, Van Voorhis, Wesley C., Geary, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243694/
https://www.ncbi.nlm.nih.gov/pubmed/22247786
http://dx.doi.org/10.1371/journal.pntd.0001412
Descripción
Sumario:New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach.

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