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Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

Hematopoietic stem cell (HSC) populations change with aging, but the extent to which this is caused by qualitative versus quantitative alterations in HSC subtypes is unclear. Using clonal assays, in this study we show that the aging HSC compartment undergoes both quantitative and qualitative changes...

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Detalles Bibliográficos
Autores principales:	Dykstra, Brad, Olthof, Sandra, Schreuder, Jaring, Ritsema, Martha, de Haan, Gerald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244040/ https://www.ncbi.nlm.nih.gov/pubmed/22110168 http://dx.doi.org/10.1084/jem.20111490

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