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A Carrier for Non-Covalent Delivery of Functional Beta-Galactosidase and Antibodies against Amyloid Plaques and IgM to the Brain
BACKGROUND: Therapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows transport of small molecules, typically <600 daltons with high octanol/water partition coefficient...
Autores principales: | Sarkar, Gobinda, Curran, Geoffry L., Mahlum, Eric, Decklever, Teresa, Wengenack, Thomas M., Blahnik, Anthony, Hoesley, Bridget, Lowe, Val J., Poduslo, Joseph F., Jenkins, Robert B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244419/ https://www.ncbi.nlm.nih.gov/pubmed/22216132 http://dx.doi.org/10.1371/journal.pone.0028881 |
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