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ADHDgene: a genetic database for attention deficit hyperactivity disorder

With a worldwide prevalence of ∼5%, attention deficit hyperactivity disorder (ADHD) has become one of the most common psychiatric disorders. The polygenetic nature of ADHD indicates that multiple genes jointly contribute to the development of this complex disease. Studies aiming to explore genetic s...

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Detalles Bibliográficos
Autores principales: Zhang, Liuyan, Chang, Suhua, Li, Zhao, Zhang, Kunlin, Du, Yang, Ott, Jurg, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245028/
https://www.ncbi.nlm.nih.gov/pubmed/22080511
http://dx.doi.org/10.1093/nar/gkr992
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author Zhang, Liuyan
Chang, Suhua
Li, Zhao
Zhang, Kunlin
Du, Yang
Ott, Jurg
Wang, Jing
author_facet Zhang, Liuyan
Chang, Suhua
Li, Zhao
Zhang, Kunlin
Du, Yang
Ott, Jurg
Wang, Jing
author_sort Zhang, Liuyan
collection PubMed
description With a worldwide prevalence of ∼5%, attention deficit hyperactivity disorder (ADHD) has become one of the most common psychiatric disorders. The polygenetic nature of ADHD indicates that multiple genes jointly contribute to the development of this complex disease. Studies aiming to explore genetic susceptibility of ADHD have been increasing in recent years. There is a growing need to integrate the genetic data from various genetic studies to provide a comprehensive data set and uniform access for convenience of in-depth data mining. So far, there has been no such effort for ADHD. To address the genetic complexity of ADHD, we developed the ADHDgene database by integrating ADHD-related genetic factors by profound literature reading. Based on the data from the literature, extended functional analysis, including linkage disequilibrium analysis, pathway-based analysis and gene mapping were performed to provide new insights into genetic causes of ADHD. Moreover, powerful search tools and a graphical browser were developed to facilitate the navigation of the data and data connections. As the first genetic database for ADHD, ADHDgene aims to provide researchers with a central genetic resource and analysis platform for ADHD and is freely available at http://adhd.psych.ac.cn/.
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spelling pubmed-32450282012-01-10 ADHDgene: a genetic database for attention deficit hyperactivity disorder Zhang, Liuyan Chang, Suhua Li, Zhao Zhang, Kunlin Du, Yang Ott, Jurg Wang, Jing Nucleic Acids Res Articles With a worldwide prevalence of ∼5%, attention deficit hyperactivity disorder (ADHD) has become one of the most common psychiatric disorders. The polygenetic nature of ADHD indicates that multiple genes jointly contribute to the development of this complex disease. Studies aiming to explore genetic susceptibility of ADHD have been increasing in recent years. There is a growing need to integrate the genetic data from various genetic studies to provide a comprehensive data set and uniform access for convenience of in-depth data mining. So far, there has been no such effort for ADHD. To address the genetic complexity of ADHD, we developed the ADHDgene database by integrating ADHD-related genetic factors by profound literature reading. Based on the data from the literature, extended functional analysis, including linkage disequilibrium analysis, pathway-based analysis and gene mapping were performed to provide new insights into genetic causes of ADHD. Moreover, powerful search tools and a graphical browser were developed to facilitate the navigation of the data and data connections. As the first genetic database for ADHD, ADHDgene aims to provide researchers with a central genetic resource and analysis platform for ADHD and is freely available at http://adhd.psych.ac.cn/. Oxford University Press 2012-01 2011-11-10 /pmc/articles/PMC3245028/ /pubmed/22080511 http://dx.doi.org/10.1093/nar/gkr992 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Zhang, Liuyan
Chang, Suhua
Li, Zhao
Zhang, Kunlin
Du, Yang
Ott, Jurg
Wang, Jing
ADHDgene: a genetic database for attention deficit hyperactivity disorder
title ADHDgene: a genetic database for attention deficit hyperactivity disorder
title_full ADHDgene: a genetic database for attention deficit hyperactivity disorder
title_fullStr ADHDgene: a genetic database for attention deficit hyperactivity disorder
title_full_unstemmed ADHDgene: a genetic database for attention deficit hyperactivity disorder
title_short ADHDgene: a genetic database for attention deficit hyperactivity disorder
title_sort adhdgene: a genetic database for attention deficit hyperactivity disorder
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245028/
https://www.ncbi.nlm.nih.gov/pubmed/22080511
http://dx.doi.org/10.1093/nar/gkr992
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