Dr.VIS: a database of human disease-related viral integration sites

Viral integration plays an important role in the development of malignant diseases. Viruses differ in preferred integration site and flanking sequence. Viral integration sites (VIS) have been found next to oncogenes and common fragile sites. Understanding the typical DNA features near VIS is useful...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xin, Liu, Qi, Cai, Qingqing, Li, Yanyun, Xu, Congjian, Li, Yixue, Li, Zuofeng, Zhang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245036/
https://www.ncbi.nlm.nih.gov/pubmed/22135288
http://dx.doi.org/10.1093/nar/gkr1142
_version_ 1782219785345433600
author Zhao, Xin
Liu, Qi
Cai, Qingqing
Li, Yanyun
Xu, Congjian
Li, Yixue
Li, Zuofeng
Zhang, Xiaoyan
author_facet Zhao, Xin
Liu, Qi
Cai, Qingqing
Li, Yanyun
Xu, Congjian
Li, Yixue
Li, Zuofeng
Zhang, Xiaoyan
author_sort Zhao, Xin
collection PubMed
description Viral integration plays an important role in the development of malignant diseases. Viruses differ in preferred integration site and flanking sequence. Viral integration sites (VIS) have been found next to oncogenes and common fragile sites. Understanding the typical DNA features near VIS is useful for the identification of potential oncogenes, prediction of malignant disease development and assessing the probability of malignant transformation in gene therapy. Therefore, we have built a database of human disease-related VIS (Dr.VIS, http://www.scbit.org/dbmi/drvis) to collect and maintain human disease-related VIS data, including characteristics of the malignant disease, chromosome region, genomic position and viral–host junction sequence. The current build of Dr.VIS covers about 600 natural VIS of 5 oncogenic viruses representing 11 diseases. Among them, about 200 VIS have viral–host junction sequence.
format Online
Article
Text
id pubmed-3245036
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-32450362012-01-10 Dr.VIS: a database of human disease-related viral integration sites Zhao, Xin Liu, Qi Cai, Qingqing Li, Yanyun Xu, Congjian Li, Yixue Li, Zuofeng Zhang, Xiaoyan Nucleic Acids Res Articles Viral integration plays an important role in the development of malignant diseases. Viruses differ in preferred integration site and flanking sequence. Viral integration sites (VIS) have been found next to oncogenes and common fragile sites. Understanding the typical DNA features near VIS is useful for the identification of potential oncogenes, prediction of malignant disease development and assessing the probability of malignant transformation in gene therapy. Therefore, we have built a database of human disease-related VIS (Dr.VIS, http://www.scbit.org/dbmi/drvis) to collect and maintain human disease-related VIS data, including characteristics of the malignant disease, chromosome region, genomic position and viral–host junction sequence. The current build of Dr.VIS covers about 600 natural VIS of 5 oncogenic viruses representing 11 diseases. Among them, about 200 VIS have viral–host junction sequence. Oxford University Press 2012-01 2011-11-30 /pmc/articles/PMC3245036/ /pubmed/22135288 http://dx.doi.org/10.1093/nar/gkr1142 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Zhao, Xin
Liu, Qi
Cai, Qingqing
Li, Yanyun
Xu, Congjian
Li, Yixue
Li, Zuofeng
Zhang, Xiaoyan
Dr.VIS: a database of human disease-related viral integration sites
title Dr.VIS: a database of human disease-related viral integration sites
title_full Dr.VIS: a database of human disease-related viral integration sites
title_fullStr Dr.VIS: a database of human disease-related viral integration sites
title_full_unstemmed Dr.VIS: a database of human disease-related viral integration sites
title_short Dr.VIS: a database of human disease-related viral integration sites
title_sort dr.vis: a database of human disease-related viral integration sites
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245036/
https://www.ncbi.nlm.nih.gov/pubmed/22135288
http://dx.doi.org/10.1093/nar/gkr1142
work_keys_str_mv AT zhaoxin drvisadatabaseofhumandiseaserelatedviralintegrationsites
AT liuqi drvisadatabaseofhumandiseaserelatedviralintegrationsites
AT caiqingqing drvisadatabaseofhumandiseaserelatedviralintegrationsites
AT liyanyun drvisadatabaseofhumandiseaserelatedviralintegrationsites
AT xucongjian drvisadatabaseofhumandiseaserelatedviralintegrationsites
AT liyixue drvisadatabaseofhumandiseaserelatedviralintegrationsites
AT lizuofeng drvisadatabaseofhumandiseaserelatedviralintegrationsites
AT zhangxiaoyan drvisadatabaseofhumandiseaserelatedviralintegrationsites

Ejemplares similares