Cargando…

A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily

The Death Domain (DD) superfamily, which is one of the largest classes of protein interaction modules, plays a pivotal role in apoptosis, inflammation, necrosis and immune cell signaling pathways. Because aberrant or inappropriate DD superfamily-mediated signaling events are associated with various...

Descripción completa

Detalles Bibliográficos
Autores principales: Kwon, Dongseop, Yoon, Jong Hwan, Shin, Soo-Yong, Jang, Tae-Ho, Kim, Hong-Gee, So, Insuk, Jeon, Ju-Hong, Park, Hyun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245059/
https://www.ncbi.nlm.nih.gov/pubmed/22135292
http://dx.doi.org/10.1093/nar/gkr1149
_version_ 1782219790524350464
author Kwon, Dongseop
Yoon, Jong Hwan
Shin, Soo-Yong
Jang, Tae-Ho
Kim, Hong-Gee
So, Insuk
Jeon, Ju-Hong
Park, Hyun Ho
author_facet Kwon, Dongseop
Yoon, Jong Hwan
Shin, Soo-Yong
Jang, Tae-Ho
Kim, Hong-Gee
So, Insuk
Jeon, Ju-Hong
Park, Hyun Ho
author_sort Kwon, Dongseop
collection PubMed
description The Death Domain (DD) superfamily, which is one of the largest classes of protein interaction modules, plays a pivotal role in apoptosis, inflammation, necrosis and immune cell signaling pathways. Because aberrant or inappropriate DD superfamily-mediated signaling events are associated with various human diseases, such as cancers, neurodegenerative diseases and immunological disorders, the studies in these fields are of great biological and clinical importance. To facilitate the understanding of the molecular mechanisms by which the DD superfamily is associated with biological and disease processes, we have developed the DD database (http://www.deathdomain.org), a manually curated database that aims to offer comprehensive information on protein–protein interactions (PPIs) of the DD superfamily. The DD database was created by manually curating 295 peer-reviewed studies that were published in the literature; the current version documents 175 PPI pairs among the 99 DD superfamily proteins. The DD database provides a detailed summary of the DD superfamily proteins and their PPI data. Users can find in-depth information that is specified in the literature on relevant analytical methods, experimental resources and domain structures. Our database provides a definitive and valuable tool that assists researchers in understanding the signaling network that is mediated by the DD superfamily.
format Online
Article
Text
id pubmed-3245059
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-32450592012-01-10 A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily Kwon, Dongseop Yoon, Jong Hwan Shin, Soo-Yong Jang, Tae-Ho Kim, Hong-Gee So, Insuk Jeon, Ju-Hong Park, Hyun Ho Nucleic Acids Res Articles The Death Domain (DD) superfamily, which is one of the largest classes of protein interaction modules, plays a pivotal role in apoptosis, inflammation, necrosis and immune cell signaling pathways. Because aberrant or inappropriate DD superfamily-mediated signaling events are associated with various human diseases, such as cancers, neurodegenerative diseases and immunological disorders, the studies in these fields are of great biological and clinical importance. To facilitate the understanding of the molecular mechanisms by which the DD superfamily is associated with biological and disease processes, we have developed the DD database (http://www.deathdomain.org), a manually curated database that aims to offer comprehensive information on protein–protein interactions (PPIs) of the DD superfamily. The DD database was created by manually curating 295 peer-reviewed studies that were published in the literature; the current version documents 175 PPI pairs among the 99 DD superfamily proteins. The DD database provides a detailed summary of the DD superfamily proteins and their PPI data. Users can find in-depth information that is specified in the literature on relevant analytical methods, experimental resources and domain structures. Our database provides a definitive and valuable tool that assists researchers in understanding the signaling network that is mediated by the DD superfamily. Oxford University Press 2012-01 2011-11-30 /pmc/articles/PMC3245059/ /pubmed/22135292 http://dx.doi.org/10.1093/nar/gkr1149 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Kwon, Dongseop
Yoon, Jong Hwan
Shin, Soo-Yong
Jang, Tae-Ho
Kim, Hong-Gee
So, Insuk
Jeon, Ju-Hong
Park, Hyun Ho
A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily
title A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily
title_full A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily
title_fullStr A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily
title_full_unstemmed A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily
title_short A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily
title_sort comprehensive manually curated protein–protein interaction database for the death domain superfamily
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245059/
https://www.ncbi.nlm.nih.gov/pubmed/22135292
http://dx.doi.org/10.1093/nar/gkr1149
work_keys_str_mv AT kwondongseop acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT yoonjonghwan acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT shinsooyong acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT jangtaeho acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT kimhonggee acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT soinsuk acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT jeonjuhong acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT parkhyunho acomprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT kwondongseop comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT yoonjonghwan comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT shinsooyong comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT jangtaeho comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT kimhonggee comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT soinsuk comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT jeonjuhong comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily
AT parkhyunho comprehensivemanuallycuratedproteinproteininteractiondatabaseforthedeathdomainsuperfamily