Cargando…
A database of immunoglobulins with integrated tools: DIGIT
The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245095/ https://www.ncbi.nlm.nih.gov/pubmed/22080506 http://dx.doi.org/10.1093/nar/gkr806 |
_version_ | 1782219798879404032 |
---|---|
author | Chailyan, Anna Tramontano, Anna Marcatili, Paolo |
author_facet | Chailyan, Anna Tramontano, Anna Marcatili, Paolo |
author_sort | Chailyan, Anna |
collection | PubMed |
description | The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed. |
format | Online Article Text |
id | pubmed-3245095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32450952012-01-10 A database of immunoglobulins with integrated tools: DIGIT Chailyan, Anna Tramontano, Anna Marcatili, Paolo Nucleic Acids Res Articles The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed. Oxford University Press 2012-01 2011-11-10 /pmc/articles/PMC3245095/ /pubmed/22080506 http://dx.doi.org/10.1093/nar/gkr806 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Chailyan, Anna Tramontano, Anna Marcatili, Paolo A database of immunoglobulins with integrated tools: DIGIT |
title | A database of immunoglobulins with integrated tools: DIGIT |
title_full | A database of immunoglobulins with integrated tools: DIGIT |
title_fullStr | A database of immunoglobulins with integrated tools: DIGIT |
title_full_unstemmed | A database of immunoglobulins with integrated tools: DIGIT |
title_short | A database of immunoglobulins with integrated tools: DIGIT |
title_sort | database of immunoglobulins with integrated tools: digit |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245095/ https://www.ncbi.nlm.nih.gov/pubmed/22080506 http://dx.doi.org/10.1093/nar/gkr806 |
work_keys_str_mv | AT chailyananna adatabaseofimmunoglobulinswithintegratedtoolsdigit AT tramontanoanna adatabaseofimmunoglobulinswithintegratedtoolsdigit AT marcatilipaolo adatabaseofimmunoglobulinswithintegratedtoolsdigit AT chailyananna databaseofimmunoglobulinswithintegratedtoolsdigit AT tramontanoanna databaseofimmunoglobulinswithintegratedtoolsdigit AT marcatilipaolo databaseofimmunoglobulinswithintegratedtoolsdigit |