Cargando…
VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors
The virulence factor database (VFDB, http://www.mgc.ac.cn/VFs/) has served as a comprehensive repository of bacterial virulence factors (VFs) for >7 years. Bacterial virulence is an exciting and dynamic field, due to the availability of complete sequences of bacterial genomes and increasing sophi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245122/ https://www.ncbi.nlm.nih.gov/pubmed/22067448 http://dx.doi.org/10.1093/nar/gkr989 |
_version_ | 1782219805117382656 |
---|---|
author | Chen, Lihong Xiong, Zhaohui Sun, Lilian Yang, Jian Jin, Qi |
author_facet | Chen, Lihong Xiong, Zhaohui Sun, Lilian Yang, Jian Jin, Qi |
author_sort | Chen, Lihong |
collection | PubMed |
description | The virulence factor database (VFDB, http://www.mgc.ac.cn/VFs/) has served as a comprehensive repository of bacterial virulence factors (VFs) for >7 years. Bacterial virulence is an exciting and dynamic field, due to the availability of complete sequences of bacterial genomes and increasing sophisticated technologies for manipulating bacteria and bacterial genomes. The intricacy of virulence mechanisms offers a challenge, and there exists a clear need to decipher the ‘language’ used by VFs more effectively. In this article, we present the recent major updates of VFDB in an attempt to summarize some of the most important virulence mechanisms by comparing different compositions and organizations of VFs from various bacterial pathogens, identifying core components and phylogenetic clades and shedding new light on the forces that shape the evolutionary history of bacterial pathogenesis. In addition, the 2012 release of VFDB provides an improved user interface. |
format | Online Article Text |
id | pubmed-3245122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32451222012-01-10 VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors Chen, Lihong Xiong, Zhaohui Sun, Lilian Yang, Jian Jin, Qi Nucleic Acids Res Articles The virulence factor database (VFDB, http://www.mgc.ac.cn/VFs/) has served as a comprehensive repository of bacterial virulence factors (VFs) for >7 years. Bacterial virulence is an exciting and dynamic field, due to the availability of complete sequences of bacterial genomes and increasing sophisticated technologies for manipulating bacteria and bacterial genomes. The intricacy of virulence mechanisms offers a challenge, and there exists a clear need to decipher the ‘language’ used by VFs more effectively. In this article, we present the recent major updates of VFDB in an attempt to summarize some of the most important virulence mechanisms by comparing different compositions and organizations of VFs from various bacterial pathogens, identifying core components and phylogenetic clades and shedding new light on the forces that shape the evolutionary history of bacterial pathogenesis. In addition, the 2012 release of VFDB provides an improved user interface. Oxford University Press 2012-01 2011-11-08 /pmc/articles/PMC3245122/ /pubmed/22067448 http://dx.doi.org/10.1093/nar/gkr989 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Chen, Lihong Xiong, Zhaohui Sun, Lilian Yang, Jian Jin, Qi VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors |
title | VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors |
title_full | VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors |
title_fullStr | VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors |
title_full_unstemmed | VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors |
title_short | VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors |
title_sort | vfdb 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factors |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245122/ https://www.ncbi.nlm.nih.gov/pubmed/22067448 http://dx.doi.org/10.1093/nar/gkr989 |
work_keys_str_mv | AT chenlihong vfdb2012updatetowardthegeneticdiversityandmolecularevolutionofbacterialvirulencefactors AT xiongzhaohui vfdb2012updatetowardthegeneticdiversityandmolecularevolutionofbacterialvirulencefactors AT sunlilian vfdb2012updatetowardthegeneticdiversityandmolecularevolutionofbacterialvirulencefactors AT yangjian vfdb2012updatetowardthegeneticdiversityandmolecularevolutionofbacterialvirulencefactors AT jinqi vfdb2012updatetowardthegeneticdiversityandmolecularevolutionofbacterialvirulencefactors |