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Lapatinib Induces Autophagy, Apoptosis and Megakaryocytic Differentiation in Chronic Myelogenous Leukemia K562 Cells

Lapatinib is an oral, small-molecule, dual tyrosine kinase inhibitor of epidermal growth factor receptors (EGFR, or ErbB/Her) in solid tumors. Little is known about the effect of lapatinib on leukemia. Using human chronic myelogenous leukemia (CML) K562 cells as an experimental model, we found that...

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Detalles Bibliográficos
Autores principales:	Huang, Huey-Lan, Chen, Yu-Chieh, Huang, Yu-Chuen, Yang, Kai-Chien, Pan, Hsin yi, Shih, Shou-Ping, Chen, Yu-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245247/ https://www.ncbi.nlm.nih.gov/pubmed/22216158 http://dx.doi.org/10.1371/journal.pone.0029014

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