The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

BACKGROUND: The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro-inflammatory cytokine IL-1β. Previous studies identified a class of diarylsulfonylurea containing compounds called Cytokine Release Inhibitory Drugs (CRIDs) that inhibited the p...

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Detalles Bibliográficos
Autores principales: Coll, Rebecca C., O'Neill, Luke A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245271/
https://www.ncbi.nlm.nih.gov/pubmed/22216309
http://dx.doi.org/10.1371/journal.pone.0029539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245271/
https://www.ncbi.nlm.nih.gov/pubmed/22216309
http://dx.doi.org/10.1371/journal.pone.0029539

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