Cargando…
Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice
BACKGROUND: Tartary buckwheat bran is an important natural source of quercetin and isoquercetin. Quercetin and isoquercetin are both powerful α-glucosidase inhibitors. Although the IC(50 )of isoquercetin as α-glucosidase inhibitor was much higher than that of quercetin, the bioavailability of isoque...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245443/ https://www.ncbi.nlm.nih.gov/pubmed/22133267 http://dx.doi.org/10.1186/1743-7075-8-85 |
_version_ | 1782219860256751616 |
---|---|
author | Zhang, Rui Yao, Yang Wang, Yingping Ren, Guixing |
author_facet | Zhang, Rui Yao, Yang Wang, Yingping Ren, Guixing |
author_sort | Zhang, Rui |
collection | PubMed |
description | BACKGROUND: Tartary buckwheat bran is an important natural source of quercetin and isoquercetin. Quercetin and isoquercetin are both powerful α-glucosidase inhibitors. Although the IC(50 )of isoquercetin as α-glucosidase inhibitor was much higher than that of quercetin, the bioavailability of isoquercetin was higher than that of quercetin. Hence, we are interested in the antidiabetic effect of isoquercetin in diabetic KK -A(y )mice. METHODS: The hypoglycemic effect of isoquercetin in a type 2 diabetic animal model (KK-A(y )mice) was studied. Isoquercetin was administrated at doses of 50, 100 and 200 mg/kg for 35 days. RESULTS: It was found that fasting blood glucose concentration was decreased with the 200 mg/kg group (p < 0.01) the most efficient compared with the diabetic control group. In addition, there was significant decrease in plasma C-peptide, triglyceride, total cholesterol and blood urea nitrogen levels after 35 days. Meanwhile, glucose tolerance was improved, and the immunoreactive of pancreatic islets β-cells was promoted. CONCLUSIONS: These results suggest that isoquercetin had a regulative role in blood glucose level and lipids, and improved the function of pancreatic islets. Isoquercetin may be useful in the treatment of type 2 diabetes mellitus. |
format | Online Article Text |
id | pubmed-3245443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32454432011-12-24 Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice Zhang, Rui Yao, Yang Wang, Yingping Ren, Guixing Nutr Metab (Lond) Research BACKGROUND: Tartary buckwheat bran is an important natural source of quercetin and isoquercetin. Quercetin and isoquercetin are both powerful α-glucosidase inhibitors. Although the IC(50 )of isoquercetin as α-glucosidase inhibitor was much higher than that of quercetin, the bioavailability of isoquercetin was higher than that of quercetin. Hence, we are interested in the antidiabetic effect of isoquercetin in diabetic KK -A(y )mice. METHODS: The hypoglycemic effect of isoquercetin in a type 2 diabetic animal model (KK-A(y )mice) was studied. Isoquercetin was administrated at doses of 50, 100 and 200 mg/kg for 35 days. RESULTS: It was found that fasting blood glucose concentration was decreased with the 200 mg/kg group (p < 0.01) the most efficient compared with the diabetic control group. In addition, there was significant decrease in plasma C-peptide, triglyceride, total cholesterol and blood urea nitrogen levels after 35 days. Meanwhile, glucose tolerance was improved, and the immunoreactive of pancreatic islets β-cells was promoted. CONCLUSIONS: These results suggest that isoquercetin had a regulative role in blood glucose level and lipids, and improved the function of pancreatic islets. Isoquercetin may be useful in the treatment of type 2 diabetes mellitus. BioMed Central 2011-12-02 /pmc/articles/PMC3245443/ /pubmed/22133267 http://dx.doi.org/10.1186/1743-7075-8-85 Text en Copyright ©2011 Zhang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Zhang, Rui Yao, Yang Wang, Yingping Ren, Guixing Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice |
title | Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice |
title_full | Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice |
title_fullStr | Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice |
title_full_unstemmed | Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice |
title_short | Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice |
title_sort | antidiabetic activity of isoquercetin in diabetic kk -a(y )mice |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245443/ https://www.ncbi.nlm.nih.gov/pubmed/22133267 http://dx.doi.org/10.1186/1743-7075-8-85 |
work_keys_str_mv | AT zhangrui antidiabeticactivityofisoquercetinindiabetickkaymice AT yaoyang antidiabeticactivityofisoquercetinindiabetickkaymice AT wangyingping antidiabeticactivityofisoquercetinindiabetickkaymice AT renguixing antidiabeticactivityofisoquercetinindiabetickkaymice |