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miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level

BACKGROUND: miR-15a and miR-16-1(miR-15a/16-1) have been implicated as tumor suppressors in chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemic cells. However the mechanism of inhibiting the proliferation of leukemic cells is poorly understood. METHODS: K562 and HL-60 cells we...

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Detalles Bibliográficos
Autores principales:	Gao, Shen-meng, Xing, Chong-yun, Chen, Chi-qi, Lin, Si-si, Dong, Pei-hong, Yu, Fu-jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245444/ https://www.ncbi.nlm.nih.gov/pubmed/22133358 http://dx.doi.org/10.1186/1756-9966-30-110

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