Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells

BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a premature ageing syndrome that affects children leading to premature death, usually from heart infarction or strokes, making this syndrome similar to normative ageing. HGPS is commonly caused by a mutation in the A-type lamin gene, LMNA (G...

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Detalles Bibliográficos
Autores principales: Mehta, Ishita S, Eskiw, Christopher H, Arican, Halime D, Kill, Ian R, Bridger, Joanna M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245614/
https://www.ncbi.nlm.nih.gov/pubmed/21838864
http://dx.doi.org/10.1186/gb-2011-12-8-r74

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