Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulatio...

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Autores principales: Begenisic, Tatjana, Spolidoro, Maria, Braschi, Chiara, Baroncelli, Laura, Milanese, Marco, Pietra, Gianluca, Fabbri, Maria E., Bonanno, Giambattista, Cioni, Giovanni, Maffei, Lamberto, Sale, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2011
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245647/
https://www.ncbi.nlm.nih.gov/pubmed/22207837
http://dx.doi.org/10.3389/fncel.2011.00029
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author Begenisic, Tatjana
Spolidoro, Maria
Braschi, Chiara
Baroncelli, Laura
Milanese, Marco
Pietra, Gianluca
Fabbri, Maria E.
Bonanno, Giambattista
Cioni, Giovanni
Maffei, Lamberto
Sale, Alessandro
author_facet Begenisic, Tatjana
Spolidoro, Maria
Braschi, Chiara
Baroncelli, Laura
Milanese, Marco
Pietra, Gianluca
Fabbri, Maria E.
Bonanno, Giambattista
Cioni, Giovanni
Maffei, Lamberto
Sale, Alessandro
author_sort Begenisic, Tatjana
collection PubMed
description Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulation in adulthood through environmental enrichment (EE) reduces brain inhibition levels and promotes recovery of spatial memory abilities, hippocampal synaptic plasticity, and visual functions in adult Ts65Dn mice.
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spelling pubmed-32456472011-12-29 Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome Begenisic, Tatjana Spolidoro, Maria Braschi, Chiara Baroncelli, Laura Milanese, Marco Pietra, Gianluca Fabbri, Maria E. Bonanno, Giambattista Cioni, Giovanni Maffei, Lamberto Sale, Alessandro Front Cell Neurosci Neuroscience Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulation in adulthood through environmental enrichment (EE) reduces brain inhibition levels and promotes recovery of spatial memory abilities, hippocampal synaptic plasticity, and visual functions in adult Ts65Dn mice. Frontiers Media S.A. 2011-12-23 /pmc/articles/PMC3245647/ /pubmed/22207837 http://dx.doi.org/10.3389/fncel.2011.00029 Text en Copyright © 2011 Begenisic, Spolidoro, Braschi, Baroncelli, Milanese, Pietra, Fabbri, Bonanno, Cioni, Maffei and Sale. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits noncommercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Begenisic, Tatjana
Spolidoro, Maria
Braschi, Chiara
Baroncelli, Laura
Milanese, Marco
Pietra, Gianluca
Fabbri, Maria E.
Bonanno, Giambattista
Cioni, Giovanni
Maffei, Lamberto
Sale, Alessandro
Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
title Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
title_full Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
title_fullStr Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
title_full_unstemmed Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
title_short Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
title_sort environmental enrichment decreases gabaergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of down syndrome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245647/
https://www.ncbi.nlm.nih.gov/pubmed/22207837
http://dx.doi.org/10.3389/fncel.2011.00029
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