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Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls

Parkinson’s disease (PD) is characterized by difficulty with the timing of movements. Data collected using the synchronization–continuation paradigm, an established motor timing paradigm, have produced varying results but with most studies finding impairment. Some of this inconsistency comes from va...

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Autores principales: Jones, Catherine R. G., Claassen, Daniel O., Yu, Minhong, Spies, Jeffrey R., Malone, Tim, Dirnberger, Georg, Jahanshahi, Marjan, Kubovy, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245650/
https://www.ncbi.nlm.nih.gov/pubmed/22207839
http://dx.doi.org/10.3389/fnint.2011.00081
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author Jones, Catherine R. G.
Claassen, Daniel O.
Yu, Minhong
Spies, Jeffrey R.
Malone, Tim
Dirnberger, Georg
Jahanshahi, Marjan
Kubovy, Michael
author_facet Jones, Catherine R. G.
Claassen, Daniel O.
Yu, Minhong
Spies, Jeffrey R.
Malone, Tim
Dirnberger, Georg
Jahanshahi, Marjan
Kubovy, Michael
author_sort Jones, Catherine R. G.
collection PubMed
description Parkinson’s disease (PD) is characterized by difficulty with the timing of movements. Data collected using the synchronization–continuation paradigm, an established motor timing paradigm, have produced varying results but with most studies finding impairment. Some of this inconsistency comes from variation in the medication state tested, in the inter-stimulus intervals (ISI) selected, and in changeable focus on either the synchronization (tapping in time with a tone) or continuation (maintaining the rhythm in the absence of the tone) phase. We sought to re-visit the paradigm by testing across four groups of participants: healthy controls, medication naïve de novo PD patients, and treated PD patients both “on” and “off” dopaminergic medication. Four finger tapping intervals (ISI) were used: 250, 500, 1000, and 2000 ms. Categorical predictors (group, ISI, and phase) were used to predict accuracy and variability using a linear mixed model. Accuracy was defined as the relative error of a tap, and variability as the deviation of the participant’s tap from group predicted relative error. Our primary finding is that the treated PD group (PD patients “on” and “off” dopaminergic therapy) showed a significantly different pattern of accuracy compared to the de novo group and the healthy controls at the 250-ms interval. At this interval, the treated PD patients performed “ahead” of the beat whilst the other groups performed “behind” the beat. We speculate that this “hastening” relates to the clinical phenomenon of motor festination. Across all groups, variability was smallest for both phases at the 500-ms interval, suggesting an innate preference for finger tapping within this range. Tapping variability for the two phases became increasingly divergent at the longer intervals, with worse performance in the continuation phase. The data suggest that patients with PD can be best discriminated from healthy controls on measures of motor timing accuracy, rather than variability.
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spelling pubmed-32456502011-12-29 Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls Jones, Catherine R. G. Claassen, Daniel O. Yu, Minhong Spies, Jeffrey R. Malone, Tim Dirnberger, Georg Jahanshahi, Marjan Kubovy, Michael Front Integr Neurosci Neuroscience Parkinson’s disease (PD) is characterized by difficulty with the timing of movements. Data collected using the synchronization–continuation paradigm, an established motor timing paradigm, have produced varying results but with most studies finding impairment. Some of this inconsistency comes from variation in the medication state tested, in the inter-stimulus intervals (ISI) selected, and in changeable focus on either the synchronization (tapping in time with a tone) or continuation (maintaining the rhythm in the absence of the tone) phase. We sought to re-visit the paradigm by testing across four groups of participants: healthy controls, medication naïve de novo PD patients, and treated PD patients both “on” and “off” dopaminergic medication. Four finger tapping intervals (ISI) were used: 250, 500, 1000, and 2000 ms. Categorical predictors (group, ISI, and phase) were used to predict accuracy and variability using a linear mixed model. Accuracy was defined as the relative error of a tap, and variability as the deviation of the participant’s tap from group predicted relative error. Our primary finding is that the treated PD group (PD patients “on” and “off” dopaminergic therapy) showed a significantly different pattern of accuracy compared to the de novo group and the healthy controls at the 250-ms interval. At this interval, the treated PD patients performed “ahead” of the beat whilst the other groups performed “behind” the beat. We speculate that this “hastening” relates to the clinical phenomenon of motor festination. Across all groups, variability was smallest for both phases at the 500-ms interval, suggesting an innate preference for finger tapping within this range. Tapping variability for the two phases became increasingly divergent at the longer intervals, with worse performance in the continuation phase. The data suggest that patients with PD can be best discriminated from healthy controls on measures of motor timing accuracy, rather than variability. Frontiers Research Foundation 2011-12-23 /pmc/articles/PMC3245650/ /pubmed/22207839 http://dx.doi.org/10.3389/fnint.2011.00081 Text en Copyright © 2011 Jones, Claassen, Yu, Spies, Malone, Dirnberger, Jahanshahi and Kubovy. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Jones, Catherine R. G.
Claassen, Daniel O.
Yu, Minhong
Spies, Jeffrey R.
Malone, Tim
Dirnberger, Georg
Jahanshahi, Marjan
Kubovy, Michael
Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls
title Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls
title_full Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls
title_fullStr Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls
title_full_unstemmed Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls
title_short Modeling Accuracy and Variability of Motor Timing in Treated and Untreated Parkinson’s Disease and Healthy Controls
title_sort modeling accuracy and variability of motor timing in treated and untreated parkinson’s disease and healthy controls
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245650/
https://www.ncbi.nlm.nih.gov/pubmed/22207839
http://dx.doi.org/10.3389/fnint.2011.00081
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