A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

How RING E3 ligases mediate E2-to-substrate ubiquitin-like protein (UBL) transfer remains unknown. Here we address how the RING E3 RBX1 positions NEDD8’s E2 (UBC12) and substrate (CUL1). We find that existing structures are incompatible with CUL1 NEDD8ylation and report a new conformation of RBX1 th...

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Detalles Bibliográficos
Autores principales: Calabrese, Matthew F., Scott, Daniel C., Duda, David M., Grace, Christy R.R., Kurinov, Igor, Kriwacki, Richard W., Schulman, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245743/
https://www.ncbi.nlm.nih.gov/pubmed/21765416
http://dx.doi.org/10.1038/nsmb.2086

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