Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A(1) adenosine receptors (A(1)Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. Here we show that physiological doses of caff...

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Detalles Bibliográficos
Autores principales: Simons, Stephen B., Caruana, Douglas A., Zhao, Meilan, Dudek, Serena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245784/
https://www.ncbi.nlm.nih.gov/pubmed/22101644
http://dx.doi.org/10.1038/nn.2962
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author Simons, Stephen B.
Caruana, Douglas A.
Zhao, Meilan
Dudek, Serena M.
author_facet Simons, Stephen B.
Caruana, Douglas A.
Zhao, Meilan
Dudek, Serena M.
author_sort Simons, Stephen B.
collection PubMed
description Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A(1) adenosine receptors (A(1)Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. Here we show that physiological doses of caffeine in vivo or A(1)R antagonists in vitro induce robust, long-lasting potentiation of synaptic transmission in rat CA2 without effect in other regions of the hippocampus.
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spelling pubmed-32457842012-07-01 Caffeine-induced synaptic potentiation in hippocampal CA2 neurons Simons, Stephen B. Caruana, Douglas A. Zhao, Meilan Dudek, Serena M. Nat Neurosci Article Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A(1) adenosine receptors (A(1)Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. Here we show that physiological doses of caffeine in vivo or A(1)R antagonists in vitro induce robust, long-lasting potentiation of synaptic transmission in rat CA2 without effect in other regions of the hippocampus. 2011-11-20 /pmc/articles/PMC3245784/ /pubmed/22101644 http://dx.doi.org/10.1038/nn.2962 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Simons, Stephen B.
Caruana, Douglas A.
Zhao, Meilan
Dudek, Serena M.
Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
title Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
title_full Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
title_fullStr Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
title_full_unstemmed Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
title_short Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
title_sort caffeine-induced synaptic potentiation in hippocampal ca2 neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245784/
https://www.ncbi.nlm.nih.gov/pubmed/22101644
http://dx.doi.org/10.1038/nn.2962
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