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Novel GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons

Neostriatal cholinergic interneurons are believed to play an important role in reinforcement mediated learning and response selection by signaling the occurrence and motivational value of behaviorally relevant stimuli through precisely timed multiphasic population responses. An important problem is...

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Detalles Bibliográficos
Autores principales: English, Daniel F., Ibanez-Sandoval, Osvaldo, Stark, Eran, Tecuapetla, Fatuel, Buzsaki, Gyorgy, Deisseroth, Karl, Tepper, James M., Koos, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245803/
https://www.ncbi.nlm.nih.gov/pubmed/22158514
http://dx.doi.org/10.1038/nn.2984
Descripción
Sumario:Neostriatal cholinergic interneurons are believed to play an important role in reinforcement mediated learning and response selection by signaling the occurrence and motivational value of behaviorally relevant stimuli through precisely timed multiphasic population responses. An important problem is to understand how these signals regulate the functioning of the neostriatum. Here we describe the synaptic organization of a novel circuit that involves direct nicotinic excitation of GABAergic interneurons and enables cholinergic interneurons to exert rapid inhibitory control of the activity of projection neurons. We also demonstrate that the dominant effect of an optogenetically reproduced pause-excitation population response of cholinergic interneurons is powerful and rapid inhibition of the firing of projection neurons that is coincident with synchronous cholinergic activation. These results reveal a previously unknown circuit mechanism that transmits reinforcement-related information of ChAT interneurons in the mouse neostriatal network.