Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle

AIMS/HYPOTHESIS: Diminished cortical filamentous actin (F-actin) has been implicated in skeletal muscle insulin resistance, yet the mechanism(s) is unknown. Here we tested the hypothesis that changes in membrane cholesterol could be a causative factor, as organised F-actin structure emanates from ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Habegger, K. M., Penque, B. A., Sealls, W., Tackett, L., Bell, L. N., Blue, E. K., Gallagher, P. J., Sturek, M., Alloosh, M. A., Steinberg, H. O., Considine, R. V., Elmendorf, J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245823/
https://www.ncbi.nlm.nih.gov/pubmed/22002007
http://dx.doi.org/10.1007/s00125-011-2334-y

Ejemplares similares

Ejemplares similares