Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase

We report key mechanistic differences between the reverse transcriptases (RT) of human immunodeficiency virus type-1 (HIV-1) and of xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus that can infect human cells. Steady and pre-steady state kinetics demonstrated that XMRV RT is...

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Detalles Bibliográficos
Autores principales: Ndongwe, Tanyaradzwa P., Adedeji, Adeyemi O., Michailidis, Eleftherios, Ong, Yee Tsuey, Hachiya, Atsuko, Marchand, Bruno, Ryan, Emily M., Rai, Devendra K., Kirby, Karen A., Whatley, Angela S., Burke, Donald H., Johnson, Marc, Ding, Shilei, Zheng, Yi-Min, Liu, Shan-Lu, Kodama, Ei-Ichi, Delviks-Frankenberry, Krista A., Pathak, Vinay K., Mitsuya, Hiroaki, Parniak, Michael A., Singh, Kamalendra, Sarafianos, Stefan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245923/
https://www.ncbi.nlm.nih.gov/pubmed/21908397
http://dx.doi.org/10.1093/nar/gkr694

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