Ultrasensitive detection of rare mutations using next-generation targeted resequencing

With next-generation DNA sequencing technologies, one can interrogate a specific genomic region of interest at very high depth of coverage and identify less prevalent, rare mutations in heterogeneous clinical samples. However, the mutation detection levels are limited by the error rate of the sequen...

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Detalles Bibliográficos
Autores principales: Flaherty, Patrick, Natsoulis, Georges, Muralidharan, Omkar, Winters, Mark, Buenrostro, Jason, Bell, John, Brown, Sheldon, Holodniy, Mark, Zhang, Nancy, Ji, Hanlee P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245950/
https://www.ncbi.nlm.nih.gov/pubmed/22013163
http://dx.doi.org/10.1093/nar/gkr861

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