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Toxicogenomic Biomarkers for Liver Toxicity
Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assessing and predicting toxicities. Further accumulation of novel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Toxicologic Pathology
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246017/ https://www.ncbi.nlm.nih.gov/pubmed/22271975 http://dx.doi.org/10.1293/tox.22.35 |
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author | Kiyosawa, Naoki Ando, Yosuke Manabe, Sunao Yamoto, Takashi |
author_facet | Kiyosawa, Naoki Ando, Yosuke Manabe, Sunao Yamoto, Takashi |
author_sort | Kiyosawa, Naoki |
collection | PubMed |
description | Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assessing and predicting toxicities. Further accumulation of novel TGx biomarkers will lead to more efficient, appropriate and cost effective drug risk assessment, reinforcing the paradigm of the conventional toxicology system with a more profound understanding of the molecular mechanisms of drug-induced toxicity. In this paper, we overview some practical strategies as well as obstacles for identifying and utilizing TGx biomarkers based on microarray analysis. Since clinical hepatotoxicity is one of the major causes of drug development attrition, the liver has been the best documented target organ for TGx studies to date, and we therefore focused on information from liver TGx studies. In this review, we summarize the current resources in the literature in regard to TGx studies of the liver, from which toxicologists could extract potential TGx biomarker gene sets for better hepatotoxicity risk assessment. |
format | Online Article Text |
id | pubmed-3246017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-32460172012-01-23 Toxicogenomic Biomarkers for Liver Toxicity Kiyosawa, Naoki Ando, Yosuke Manabe, Sunao Yamoto, Takashi J Toxicol Pathol Review Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assessing and predicting toxicities. Further accumulation of novel TGx biomarkers will lead to more efficient, appropriate and cost effective drug risk assessment, reinforcing the paradigm of the conventional toxicology system with a more profound understanding of the molecular mechanisms of drug-induced toxicity. In this paper, we overview some practical strategies as well as obstacles for identifying and utilizing TGx biomarkers based on microarray analysis. Since clinical hepatotoxicity is one of the major causes of drug development attrition, the liver has been the best documented target organ for TGx studies to date, and we therefore focused on information from liver TGx studies. In this review, we summarize the current resources in the literature in regard to TGx studies of the liver, from which toxicologists could extract potential TGx biomarker gene sets for better hepatotoxicity risk assessment. The Japanese Society of Toxicologic Pathology 2009-04-06 2009-03 /pmc/articles/PMC3246017/ /pubmed/22271975 http://dx.doi.org/10.1293/tox.22.35 Text en ©2009 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Review Kiyosawa, Naoki Ando, Yosuke Manabe, Sunao Yamoto, Takashi Toxicogenomic Biomarkers for Liver Toxicity |
title | Toxicogenomic Biomarkers for Liver Toxicity |
title_full | Toxicogenomic Biomarkers for Liver Toxicity |
title_fullStr | Toxicogenomic Biomarkers for Liver Toxicity |
title_full_unstemmed | Toxicogenomic Biomarkers for Liver Toxicity |
title_short | Toxicogenomic Biomarkers for Liver Toxicity |
title_sort | toxicogenomic biomarkers for liver toxicity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246017/ https://www.ncbi.nlm.nih.gov/pubmed/22271975 http://dx.doi.org/10.1293/tox.22.35 |
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