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Therapeutic Hypothermia in Stroke and Traumatic Brain Injury

Therapeutic hypothermia (TH) is considered to improve survival with favorable neurological outcome in the case of global cerebral ischemia after cardiac arrest and perinatal asphyxia. The efficacy of hypothermia in acute ischemic stroke (AIS) and traumatic brain injury (TBI), however, is not well st...

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Autores principales: Faridar, Alireza, Bershad, Eric M., Emiru, Tenbit, Iaizzo, Paul A., Suarez, Jose I., Divani, Afshin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246360/
https://www.ncbi.nlm.nih.gov/pubmed/22207862
http://dx.doi.org/10.3389/fneur.2011.00080
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author Faridar, Alireza
Bershad, Eric M.
Emiru, Tenbit
Iaizzo, Paul A.
Suarez, Jose I.
Divani, Afshin A.
author_facet Faridar, Alireza
Bershad, Eric M.
Emiru, Tenbit
Iaizzo, Paul A.
Suarez, Jose I.
Divani, Afshin A.
author_sort Faridar, Alireza
collection PubMed
description Therapeutic hypothermia (TH) is considered to improve survival with favorable neurological outcome in the case of global cerebral ischemia after cardiac arrest and perinatal asphyxia. The efficacy of hypothermia in acute ischemic stroke (AIS) and traumatic brain injury (TBI), however, is not well studied. Induction of TH typically requires a multimodal approach, including the use of both pharmacological agents and physical techniques. To date, clinical outcomes for patients with either AIS or TBI who received TH have yielded conflicting results; thus, no adequate therapeutic consensus has been reached. Nevertheless, it seems that by determining optimal TH parameters and also appropriate applications, cooling therapy still has the potential to become a valuable neuroprotective intervention. Among the various methods for hypothermia induction, intravascular cooling (IVC) may have the most promise in the awake patient in terms of clinical outcomes. Currently, the IVC method has the capability of more rapid target temperature attainment and more precise control of temperature. However, this technique requires expertise in endovascular surgery that can preclude its application in the field and/or in most emergency settings. It is very likely that combining neuroprotective strategies will yield better outcomes than utilizing a single approach.
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spelling pubmed-32463602011-12-29 Therapeutic Hypothermia in Stroke and Traumatic Brain Injury Faridar, Alireza Bershad, Eric M. Emiru, Tenbit Iaizzo, Paul A. Suarez, Jose I. Divani, Afshin A. Front Neurol Neuroscience Therapeutic hypothermia (TH) is considered to improve survival with favorable neurological outcome in the case of global cerebral ischemia after cardiac arrest and perinatal asphyxia. The efficacy of hypothermia in acute ischemic stroke (AIS) and traumatic brain injury (TBI), however, is not well studied. Induction of TH typically requires a multimodal approach, including the use of both pharmacological agents and physical techniques. To date, clinical outcomes for patients with either AIS or TBI who received TH have yielded conflicting results; thus, no adequate therapeutic consensus has been reached. Nevertheless, it seems that by determining optimal TH parameters and also appropriate applications, cooling therapy still has the potential to become a valuable neuroprotective intervention. Among the various methods for hypothermia induction, intravascular cooling (IVC) may have the most promise in the awake patient in terms of clinical outcomes. Currently, the IVC method has the capability of more rapid target temperature attainment and more precise control of temperature. However, this technique requires expertise in endovascular surgery that can preclude its application in the field and/or in most emergency settings. It is very likely that combining neuroprotective strategies will yield better outcomes than utilizing a single approach. Frontiers Research Foundation 2011-12-27 /pmc/articles/PMC3246360/ /pubmed/22207862 http://dx.doi.org/10.3389/fneur.2011.00080 Text en Copyright © 2011 Faridar, Bershad, Emiru, Iaizzo, Suarez and Divani. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Faridar, Alireza
Bershad, Eric M.
Emiru, Tenbit
Iaizzo, Paul A.
Suarez, Jose I.
Divani, Afshin A.
Therapeutic Hypothermia in Stroke and Traumatic Brain Injury
title Therapeutic Hypothermia in Stroke and Traumatic Brain Injury
title_full Therapeutic Hypothermia in Stroke and Traumatic Brain Injury
title_fullStr Therapeutic Hypothermia in Stroke and Traumatic Brain Injury
title_full_unstemmed Therapeutic Hypothermia in Stroke and Traumatic Brain Injury
title_short Therapeutic Hypothermia in Stroke and Traumatic Brain Injury
title_sort therapeutic hypothermia in stroke and traumatic brain injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246360/
https://www.ncbi.nlm.nih.gov/pubmed/22207862
http://dx.doi.org/10.3389/fneur.2011.00080
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