Cargando…

Thymidine Kinase 2 Deficiency-Induced Mitochondrial DNA Depletion Causes Abnormal Development of Adipose Tissues and Adipokine Levels in Mice

Mammal adipose tissues require mitochondrial activity for proper development and differentiation. The components of the mitochondrial respiratory chain/oxidative phosphorylation system (OXPHOS) are encoded by both mitochondrial and nuclear genomes. The maintenance of mitochondrial DNA (mtDNA) is a k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villarroya, Joan, Dorado, Beatriz, Vilà, Maya R., Garcia-Arumí, Elena, Domingo, Pere, Giralt, Marta, Hirano, Michio, Villarroya, Francesc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246498/ https://www.ncbi.nlm.nih.gov/pubmed/22216345 http://dx.doi.org/10.1371/journal.pone.0029691

Ejemplares similares

HIV-1 Infection and the PPARγ-Dependent Control of Adipose Tissue Physiology
por: Giralt, Marta, et al.
Publicado: (2009)

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
por: Villarroya, Joan, et al.
Publicado: (2018)

A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
por: Mestres-Arenas, Alberto, et al.
Publicado: (2021)

Impaired expression of mitochondrial and adipogenic genes in adipose tissue from a patient with acquired partial lipodystrophy (Barraquer-Simons syndrome): a case report
por: Guallar, Jordi P, et al.
Publicado: (2008)

Secretory Proteome of Brown Adipocytes in Response to cAMP-Mediated Thermogenic Activation
por: Villarroya, Joan, et al.
Publicado: (2019)

Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
por: Domingo, Pere, et al.
Publicado: (2022)

Effects of Switching from Stavudine to Raltegravir on Subcutaneous Adipose Tissue in HIV-Infected Patients with HIV/HAART-Associated Lipodystrophy Syndrome (HALS). A Clinical and Molecular Study
por: Domingo, Pere, et al.
Publicado: (2014)

The Molecular Signature of HIV-1-Associated Lipomatosis Reveals Differential Involvement of Brown and Beige/Brite Adipocyte Cell Lineages
por: Cereijo, Rubén, et al.
Publicado: (2015)

Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning
por: Castellá, Moisés, et al.
Publicado: (2023)

Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System
por: Moure, Ricardo, et al.
Publicado: (2018)

Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy
por: Domingo, Pere, et al.
Publicado: (2022)

PPARs in the Control of Uncoupling Proteins Gene Expression
por: Villarroya, Francesc, et al.
Publicado: (2007)

Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency
por: Garone, Caterina, et al.
Publicado: (2014)

Advances in Thymidine Kinase 2 Deficiency: Clinical Aspects, Translational Progress, and Emerging Therapies
por: Berardo, Andres, et al.
Publicado: (2022)

Bone Morphogenetic Protein-8B Levels at Birth and in the First Year of Life: Relation to Metabolic-Endocrine Variables and Brown Adipose Tissue Activity
por: Garcia-Beltran, Cristina, et al.
Publicado: (2022)

Late-onset thymidine kinase 2 deficiency: a review of 18 cases
por: Domínguez-González, Cristina, et al.
Publicado: (2019)

Fibroblast growth factor 21 in breast milk controls neonatal intestine function
por: Gavaldà-Navarro, Aleix, et al.
Publicado: (2015)

The relative deficit of GDF15 in adolescent girls with PCOS can be changed into an abundance that reduces liver fat
por: de Zegher, Francis, et al.
Publicado: (2021)

Author Correction: The relative deficit of GDF15 in adolescent girls with PCOS can be changed into an abundance that reduces liver fat
por: de Zegher, Francis, et al.
Publicado: (2021)

The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity
por: Peyrou, Marion, et al.
Publicado: (2020)

Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners
por: Campderrós, Laura, et al.
Publicado: (2020)

THYMIDINE TRIPHOSPHATE SYNTHESIS IN TETRAHYMENA : I. Studies on Thymidine Kinase
por: Shoup, G. D., et al.
Publicado: (1966)

INDUCIBILITY OF THYMIDINE KINASE BY THYMIDINE AS A FUNCTION OF INTERPHASE STAGE
por: Hotta, Yasuo, et al.
Publicado: (1965)

FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations
por: Morón-Ros, Samantha, et al.
Publicado: (2020)

Uridine Metabolism in HIV-1-Infected Patients: Effect of Infection, of Antiretroviral Therapy and of HIV-1/ART-Associated Lipodystrophy Syndrome
por: Domingo, Pere, et al.
Publicado: (2010)

Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase
por: Harada, Naomoto, et al.
Publicado: (2023)

FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH)
por: Urraza-Robledo, Arguiñe Ivonne, et al.
Publicado: (2021)

Thymidine kinase in breast cancer.
por: Robertson, J. F., et al.
Publicado: (1990)

Adipose Tissue and Adipokines: The Association with and Application of Adipokines in Obesity
por: Khan, Muhammad, et al.
Publicado: (2014)

Retrospective natural history of thymidine kinase 2 deficiency
por: Garone, Caterina, et al.
Publicado: (2018)

Polymorphisms of Pyrimidine Pathway Enzymes Encoding Genes and HLA-B*40∶01 Carriage in Stavudine-Associated Lipodystrophy in HIV-Infected Patients
por: Domingo, Pere, et al.
Publicado: (2013)

FGF21 and Cardiac Physiopathology
por: Planavila, Anna, et al.
Publicado: (2015)

Thymidine Kinase 2 Deficiency-Induced mtDNA Depletion in Mouse Liver Leads to Defect β-Oxidation
por: Zhou, Xiaoshan, et al.
Publicado: (2013)

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging
por: Schneider, Jaime L, et al.
Publicado: (2015)

Association of Thymidylate Synthase Polymorphisms with Acute Pancreatitis and/or Peripheral Neuropathy in HIV-Infected Patients on Stavudine-Based Therapy
por: Domingo, Pere, et al.
Publicado: (2013)

Meteorin-like levels are associated with active brown adipose tissue in early infancy
por: Garcia-Beltran, Cristina, et al.
Publicado: (2023)

Serum thymidine kinase in acute leukaemia.
por: Hagberg, H., et al.
Publicado: (1984)

Collaborative model for diagnosis and treatment of very rare diseases: experience in Spain with thymidine kinase 2 deficiency
por: Domínguez-González, Cristina, et al.
Publicado: (2021)

3'-Amino thymidine affinity matrix for the purification of herpes simplex virus thymidine kinase.
por: Tung, P. P., et al.
Publicado: (1996)

Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression
por: Latorre, Jessica, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dr657d05fegjl9cl766qspv2q9